Road traffic accident risk in patients with diabetes mellitus receiving blood glucose‐lowering drugs. Prospective follow‐up study

Abstract

A slightly increased risk of being involved in a road traffic accident was observed for drivers prescribed insulin, while no increased risk was observed for drivers prescribed oral glucose-lowering agents. The increased risk observed for insulin users was similar to that observed for users of drugs for peptic ulcer and gastro-oesophageal reflux disease.

Medication use and the risk of motor vehicle collisions among licensed drivers: A systematic review

“…Of the six studies that reported outcome measures for Insulin, only two reported a statistically significant increase in MVC. 66,75 The other four studies reported no statistically significant associations. 71,84,85,88 This may be attributed to the adjustment of covariates.…”

“…63-89 The included studies spanned from 1992-2013. Of these studies, eight (29.6%) were conducted in Norway, 69,70,72,73,75,77,79,82 six (22.2%) in the United States, 63,64,81,83-85 five (18.5%) from Canada, 65,66,86-88 three (11.1%) from England, 71,74,76 three (11.1%) from France, 67,78,80 one (3.7%) from the Netherlands, 68 and one (3.7%) from Taiwan. 89 Eleven (40.7%) of these studies were cohort designs, while the rest consisted of case-control or variations of a case-control design.…”

“…Six studies investigated three antihyperglycemic medications which included Insulin, 66,71,75,84,85,88 Metformin, 88 and Sulfonylurea 88 (Figure 6). Of the six studies that reported outcome measures for Insulin, only two reported a statistically significant increase in MVC.…”

FMCSA's Medical Review Board

“…In addition, a large population-based cohort study from Norway subsequently demonstrated elevated crash risks for both insulin use (standardized incidence ratio = 1.4, 95% CI = 1.2-1.6) and oral agents (standardized incidence ratio = 1.2, 95% CI = 1.0-1.3). 38 The MRB subsequently concluded that the evidence report and the MEP were out of date and the entire topic required revisiting. 13 The primary author of the evidence report subsequently concurred that it was out of date (S. J. Treager, DPhil, personal communication, January 2010).…”

The Benzodiazepine Stigma Persists

“…[3][4][5][6][7][8][9][10][11][12][13] Some of these medications have been associated with impairment in on-the-road driving tests and psychomotor tests in addition to being associated with motor vehicle accidents.…”