We calculate the proton lifetime and discuss topological defects in a wide class of non-supersymmetric (non-SUSY) SO(10) and E(6) Grand Unified Theories (GUTs), broken via left-right subgroups with one or two intermediate scales (a total of 9 different scenarios with and without D-parity), including the important effect of threshold corrections. By performing a goodness of fit test for unification using the two-loop renormalisation group evolution equations (RGEs), we find that the inclusion of threshold corrections significantly affects the proton lifetime, allowing several scenarios, which would otherwise be excluded, to survive. Indeed we find that the threshold corrections are a saviour for many non-SUSY GUTs. For each scenario we analyse the homotopy of the vacuum manifold to estimate the possible emergence of topological defects.