Roadmap on nanomedicine for the central nervous system

Abstract

In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier (BBB) acts as a obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the central nervous system one of the most significant challenges in medicine. In this Roadmap article, we present the status of the timeliest developments in the field and identify the outstanding challenges and opportunities that exist. The format of the Roadmap, whereby experts in each discipline share their viewpoint and present their vision, reflects the dynamic and multidisciplinary nature of this research area, and is intended to generate dialogue and collaboration across traditional subject areas. It is stressed here that this article is not intended to act as a comprehensive review article, but rather an up-to-date and forward-looking summary of research methodologies pertaining to the treatment of pathologies at the level of the central nervous system.

Revolutionizing Healthcare through Applications and Challenges of Nanomaterials in Targeted Drug Delivery and Therapeutics

“…The zeta potential of the nanoparticles was measured by employing a Zetasizer to assess their solidness and charge. The drug release energy from the nanomaterials was considered beneath different physiological conditions, imitating the complex situations experienced in vivo [19]. The discharge profiles were checked over time, and scientific models such as the Higuchi show were connected to analyze the discharge instruments:…”