BACKGROUND: With the rapid development of higher education in China, vocational colleges are developing rapidly. However, most higher vocational colleges have a short history of running schools, insufficient management systems, averaged student quality, low government social recognition, and poor employment quality, making vocational college students’ mental health issues prominent. OBJECTIVES: The purposes are to evaluate and intervene in students’ mental health issues in vocational colleges, thereby formulating corresponding intervention mechanisms. METHODS: The questionnaires and in-depth interviews are utilized to investigate and collect students’ mental health in vocational colleges. Corresponding intervention mechanisms are formulated according to the results obtained. RESULTS: A total of 510 equivalent questionnaires are distributed to three different local vocational colleges. Finally, 496 questionnaires are returned, of which 441 questionnaires are valid. Investigation and analysis results show that only 34.82%of students are considered mentally healthy and relatively healthy in terms of mental health, while 22.22%have some or severe mental health issues. Employment brings the greatest pressure. Further investigation of the students’ personalities shows that 54.88%of students are classified as impulsive personalities, and 40.82%are inferiority personalities, clarifying students’ mental health issues. Finally, intervention mechanisms are formulated from three perspectives: preventive intervention, response intervention, and follow-up intervention to improve students’ mental health issues. CONCLUSION: The mental health issues of students in vocational colleges are assessed and analyzed clearly, making the intervention measures more targeted, which can provide a reference for the intervention and evaluation of students’ mental health issues in the future.