Robert R. Wilson (1914–2000): the first scientist to propose particle therapy—use of particle beam for cancer treatment

Endo, Masahiro

doi:10.1007/s12194-017-0428-z

Cited by 14 publications

(6 citation statements)

References 4 publications

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“…Particle therapy as a form of cancer treatment was originally proposed by Robert Wilson in 1946. 4 Compared to photons which continually deposit dose throughout tissue and exhibit an exit dose, the dose distribution of protons forms a Bragg peak, denoting maximal dose deposition at a finite tissue depth followed by a sharp dose falloff with no exit dose. This dosimetric difference, in turn, can theoretically translate into a clinically relevant therapeutic advantage.…”

Section: Introductionmentioning

confidence: 99%

Intensity modulated proton therapy (IMPT) – The future of IMRT for head and neck cancer

et al. 2019

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Summary Radiation therapy plays an integral role in the management of head and neck cancers (HNCs). While most HNC patients have historically been treated with photon-based radiation techniques such as intensity modulated radiation therapy (IMRT), there is a growing awareness of the potential clinical benefit of proton therapy over IMRT in the definitive, postoperative and reirradiation settings given the unique physical properties of protons. Intensity modulated proton therapy (IMPT), also known as “pencil beam proton therapy,” is a sophisticated mode of proton therapy that is analogous to IMRT and an active area of investigation in cancer care. Multifield optimization IMPT allows for high quality plans that can target superficially located HNCs as well as large neck volumes while significantly reducing integral doses. Several dosimetric studies have demonstrated the superiority of IMPT over IMRT to improve dose sparing of nearby organs such as the larynx, salivary glands, and esophagus. Evidence of the clinical translation of these dosimetric advantages has been demonstrated with documented toxicity reductions (such as decreased feeding tube dependency) after IMPT for patients with HNCs. While there are relative challenges to IMPT planning that exist today such as particle range uncertainties and high sensitivity to anatomical changes, ongoing investigations in image-guidance techniques and robust optimization methods are promising. A systematic approach towards utilizing IMPT and additional prospective studies are also necessary in order to more accurately estimate the clinical benefit of IMPT over IMRT and passive proton therapy on a case-by-case basis for patients with sub-site specific HNCs.

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Section: Introductionmentioning

confidence: 99%

Intensity modulated proton therapy (IMPT) – The future of IMRT for head and neck cancer

et al. 2019

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“…Physicist Robert Wilson originally proposed using proton therapy to target small volumes in 1946, and approximately a decade later, patients began treatment with proton therapy (3)(4)(5). The emergence of this particle therapy has theoretical benefits over photon therapy.…”

Section: Introductionmentioning

confidence: 99%

A narrative review of intensity-modulated proton therapy for head and neck cancer

Mohamed¹,

Li²,

Lee³

2023

Ther Radiol Oncol

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Background and Objective: We aim to summarize and discuss the literature on intensity-modulated proton therapy (IMPT) in head and neck cancer and elucidate its benefits and limitations in a clinical setting.Head and neck cancer treatment involves a multi-disciplinary approach, with radiation therapy playing an integral role. Historically, photon therapy techniques, such as intensity-modulated radiation therapy (IMRT), have been utilized to manage head and neck cancer. In recent years, proton therapy has grown in popularity as a potential radiotherapy to provide favorable outcomes and limit toxicities in an aging patient population.The physical properties of protons provide a dosimetric advantage, where protons are deposited at a narrow range of tissue depth, termed the "Bragg peak". Localization of the Bragg peak onto the desired target volume and the minimal to no exit dose of protons limit healthy tissue radiation. IMPT is the most recently developed delivery method of delivering protons, where it uses a pencil beam manipulated by magnets. In hopes to improve treatment outcomes and reduce toxicities, studies on IMPT have gained traction in its role in treating head and neck cancers. including oropharyngeal, nasopharyngeal, and sinonasal cancer. Methods:To adequately review the literature on IMPT in head and neck cancer, we conducted a PubMed search using the following search syntax: (("intensity-modulated proton therapy" OR "IMPT" OR "pencil beam scanning" OR "scanning beam proton therapy") AND "head and neck cancer"). No timeframe filters were selected. Articles reported on clinical trial results in English were included in the study.

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“…Proton therapy (PT) was first proposed by Robert R Wilson in 1946 [ 1 ] because of the unique dosimetric property of proton beams known as the Bragg peak. In theory, a proton beam traversing a medium deposits a relatively small amount of radiation before it reaches the Bragg peak, and no radiation beyond it.…”

Section: Introductionmentioning

confidence: 99%

Proton Therapy for Prostate Cancer: Challenges and Opportunities

Poon

et al. 2022

Cancers

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The dosimetric advantages of proton therapy (PT) treatment plans are demonstrably superior to photon-based external beam radiotherapy (EBRT) for localized prostate cancer, but the reported clinical outcomes are similar. This may be due to inadequate dose prescription, especially in high-risk disease, as indicated by the ASCENDE-RT trial. Alternatively, the lack of clinical benefits with PT may be attributable to improper dose delivery, mainly due to geometric and dosimetric uncertainties during treatment planning, as well as delivery procedures that compromise the dose conformity of treatments. Advanced high-precision PT technologies, and treatment planning and beam delivery techniques are being developed to address these uncertainties. For instance, external magnetic resonance imaging (MRI)-guided patient setup rooms are being developed to improve the accuracy of patient positioning for treatment. In-room MRI-guided patient positioning systems are also being investigated to improve the geometric accuracy of PT. Soon, high-dose rate beam delivery systems will shorten beam delivery time to within one breath hold, minimizing the effects of organ motion and patient movements. Dual-energy photon-counting computed tomography and high-resolution Monte Carlo-based treatment planning systems are available to minimize uncertainties in dose planning calculations. Advanced in-room treatment verification tools such as prompt gamma detector systems will be used to verify the depth of PT. Clinical implementation of these new technologies is expected to improve the accuracy and dose conformity of PT in the treatment of localized prostate cancers, and lead to better clinical outcomes. Improvement in dose conformity may also facilitate dose escalation, improving local control and implementation of hypofractionation treatment schemes to improve patient throughput and make PT more cost effective.

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Robert R. Wilson (1914–2000): the first scientist to propose particle therapy—use of particle beam for cancer treatment

Cited by 14 publications

References 4 publications

Intensity modulated proton therapy (IMPT) – The future of IMRT for head and neck cancer

Intensity modulated proton therapy (IMPT) – The future of IMRT for head and neck cancer

A narrative review of intensity-modulated proton therapy for head and neck cancer

Proton Therapy for Prostate Cancer: Challenges and Opportunities

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