We present the case of a 65-year-old man who was diagnosed at colonoscopy with a stenosing sigmoid adenocarcinoma 30 cm from the anal verge. Further investigations included CT, which showed a large sigmoid colon tumour with signs of a colovesical fistula and no distant metastases. CT colonography demonstrated no other proximal lesion. Cystoscopy demonstrated bladder dome retraction; the biopsy, however, showed no evidence of malignancy. In collaboration with a urologist, en bloc laparoscopic sigmoidectomy and resection of the bladder dome was performed, with closure of the bladder defect in two planes. Double J catheters were not used since the location (in the bladder dome) of the lesion allowed for safe resection without compromising the ureteric orifices in the trigone.A circular stapled end-to-end intracorporeal colorectal anastomosis was performed. The vascularity was assessed with the aid of indocyanine green fluorescence.The postoperative recovery was uneventful, with early start of diet and ambulation. The patient was discharged on the sixth postoperative day.High pressure cystography was performed in the third postoperative week without evidence of leakage. The final histopathological report showed a well-differentiated infiltrative adenocarcinoma with perineural invasion but free margins, pT4bN0.The magnified view provided by laparoscopy can help identify an adequate dissection plane. Laparoscopic en bloc resection of locally advanced colon cancer requiring resection of neighbouring organs is, however, a technically demanding procedure, and should be performed by laparoscopic surgeons with extensive experience in advanced colorectal cancer surgery.