Robotic stereotaxic system based on 3D skull reconstruction to improve surgical accuracy and speed

Ly, Phuong T.; Lucas, Alexandra; Pun, Sio Hang; Dondzillo, Anna; Liu, Chao; Klug, Achim; Lei, Tim C.

doi:10.1016/j.jneumeth.2020.108955

Cited by 8 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As both landmark systems are not visually detectable from the dorsal surface of the skull, they can only be visualized in an intersectional view of the imaged skull or brain and require exposure of the brain or image guidance during surgery. Stereotaxic surgery in rodent brains is rarely performed in combination with CT or MRI, but emerging camera-guided robotic systems for intra-cranial surgeries 73 and neural networks 74 can help to identify less variable cranial landmarks and potentially provide additional anatomical reference points.…”

Section: Skull-derived Stereotaxic Coordinate System For Accurate Sig...mentioning

confidence: 99%

Multimodal 3D Mouse Brain Atlas Framework with the Skull-Derived Coordinate System

Perens

Salinas²,

Roostalu³

et al. 2023

Neuroinform

View full text Add to dashboard Cite

Magnetic resonance imaging and light-sheet microscopy enable non-disruptive 3-dimensional imaging of mouse brains. A combination of complementary information from these modalities is essential for studying disease progression, developing effective therapies, and translating ndings into clinical procedures. Although both technologies rely on atlas mapping for quantitative analysis, integration of data from these modalities has been challenging due to morphological differences between brain samples. In this study, we have developed a multimodal atlas framework that includes brain templates based on both imaging modalities, region delineations from the Allen's Common Coordinate Framework, and a skull-derived stereotaxic coordinate system. The coordinate system allows users to precisely translate spatial positions from ex vivo modalities to locations in a living mouse brain. Consequently, the atlas resource, which is accessible via NeuroPedia, will allow the combination of results obtained from in vivo and ex vivo mouse brain measurements and accurate navigation in the brain during stereotaxic interventions.

show abstract

Section: Skull-derived Stereotaxic Coordinate System For Accurate Sig...mentioning

confidence: 99%