Robotically guided radiosurgery for children

Giller, Cole A.; Berger, Brian D.; Pistenmaa, David; Sklar, Frederick H.; Weprin, Bradley E.; Shapiro, Kenneth; Winick, Naomi J.; Mulne, Arlynn F.; Delp, Janice L.; Gilio, Joseph P.; Gall, Kenneth P.; Dicke, Karel A.; Swift, Dale M.; Sacco, David; Harris-Henderson, Kesha; Bowers, Daniel C.

doi:10.1002/pbc.20267

Cited by 45 publications

(26 citation statements)

References 40 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A variety of fractionation schemes have been used in adult spinal stereotactic radiotherapy with fraction doses ranging from 6 to 30 Gy in 1 to 5 fractions, and rare severe radiation dose-related myelopathy was identified in this range1,5,6). Nevertheless, the tolerability and feasibility of hypofractionated radiotherapy in children is rarely reported and limited to pediatric CNS tumors7,8). To our knowledge, this is the first report of Cyberknife® stereotactic hypofractionated radiotherapy in childhood spinal metastasis.…”

Section: Discussionmentioning

confidence: 97%

Successful Treatment of Infantile Fibrosarcoma Spinal Metastasis by Chemotherapy and Stereotactic Hypofractionated Radiotherapy

Cheng

Lin

et al. 2013

J Korean Neurosurg Soc

View full text Add to dashboard Cite

We report a case of infantile fibrosarcoma in an 8-month-old boy manifested as a right-sided lower leg mass. Repeated local recurrence and distant metastasis were noted during the following three-year period. Whole body fluoro-deoxyglucose positron emission tomography scan revealed an asymptomatic metastasis involving the fourth lumbar vertebrae. The patient received chemotherapy (VAC regimen) with Cyberknife® stereotactic hypofractionated radiotherapy (26 Gy; 4 fractions). This treatment reduced tumor size by 23% without acute radiation toxicity even after 33 months. This case suggests that combining chemotherapy and this form of radiotherapy may be safe and effective against childhood spinal metastasis.

show abstract

Section: Discussionmentioning

confidence: 97%

Successful Treatment of Infantile Fibrosarcoma Spinal Metastasis by Chemotherapy and Stereotactic Hypofractionated Radiotherapy

Cheng

Lin

et al. 2013

J Korean Neurosurg Soc

View full text Add to dashboard Cite

show abstract

“…It uses a large number of beams and allows the position of the robot to be updated with real-time radiographs obtained during treatment, thereby achieving precision and accuracy that rivals that of the frame-based systems. It may also offer advantages particularly important for pediatric patients (treatment of young children with thin skulls unsuitable for frame-based methods, no need for rigid head fixation and possible avoidance of general anesthesia) (183).…”

Section: Stereotactic Radiosurgerymentioning

confidence: 99%

Craniopharyngiomas

et al. 2006

View full text Add to dashboard Cite

Craniopharyngiomas are rare, mainly sellar/parasellar, epithelial tumors diagnosed during childhood or adult life. Histologically, two primary subtypes have been recognized (adamantinomatous and papillary) with an as yet, unclarified pathogenesis. They may present with a variety of manifestations (neurological, visual, and hypothalamo-pituitary). Despite their benign histological appearance, they often show an unpredictable growth pattern, which, combined with the lack of randomized studies, poses significant difficulties in the establishment of an optimal therapeutic protocol. This should focus on the prevention of recurrence(s), improvement of survival, reduction of the significant disease and treatment-related morbidity (endocrine, visual, hypothalamic, neurobehavioral, and cognitive), and preservation of the quality of life. Currently, surgical excision followed by external beam irradiation, in cases of residual tumor, is the main treatment option. Intracystic irradiation or bleomycin, stereotactic radiosurgery, or radiotherapy and systemic chemotherapy are alternative approaches; their place in the management plan remains to be assessed in adequately powered long-term trials. Apart from the type of treatment, the identification of clinical and imaging parameters that will predict patients with a better prognosis is difficult. The central registration of patients with these challenging tumors may provide correlates between treatments and outcomes and establish prognostic factors at the pathological or molecular level that may further guide us in the future.

show abstract

“…Durable local control of rhabdoid tumors after SRS has been reported in the literature [7][8][9] . There may be potential applications of SRS in selected pediatric patients with intracranial or skull base rhabdoid tumors.…”

Section: B Amentioning

confidence: 99%

Successful Treatment of a Skull Base Malignant Rhabdoid Tumor with Surgery, Chemotherapy and Gamma Knife-Based Stereotactic Radiosurgery in a Young Child

Witt

Timmerman

2007

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

Most childhood rhabdoid tumors occur in the kidney or central nervous system but they can occur in other sites and they usually run an aggressive clinical course. We report a case of an 8-month-old boy with a right temporal bone rhabdoid tumor treated with surgery, chemotherapy and Gamma Knife-based stereotactic radiosurgery. The patient remained alive after 61 months and repeat magnetic resonance imaging (MRI) of the brain showed no evidence of recurrence. There were no obvious endocrine deficits or growth abnormalities at last follow-up. Gamma Knife-based stereotactic radiosurgery may have a role in the management of very young children with skull base tumors.

show abstract

Robotically guided radiosurgery for children

Abstract: Cyberknife radiosurgery can be used to achieve local control for some children with CNS tumors without the need for rigid head fixation.

Cited by 45 publications

References 40 publications

Successful Treatment of Infantile Fibrosarcoma Spinal Metastasis by Chemotherapy and Stereotactic Hypofractionated Radiotherapy

Successful Treatment of Infantile Fibrosarcoma Spinal Metastasis by Chemotherapy and Stereotactic Hypofractionated Radiotherapy

Craniopharyngiomas

Successful Treatment of a Skull Base Malignant Rhabdoid Tumor with Surgery, Chemotherapy and Gamma Knife-Based Stereotactic Radiosurgery in a Young Child

Contact Info

Product

Resources

About