Robust boron nanoplatform provokes potent tumoricidal activities via inhibiting heat shock protein

Zhao, Yuying; Liu, Ning; Liu, Piaoxue; Fan, Taojian; Ma, Rui; Hong, Huijie; Chen, Xiao‐Jia; Xie, Zhongjian; Zhang, Han; Wang, Qi; Chen, Tongkai

doi:10.1016/j.ajps.2022.06.003

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…121,122 However, heat shock proteins (HSPs) overexpressed by tumor cells induce heat resistance to PTT under mild hyperthermia conditions. 123,124 To solve the problem of heat resistance of PTT, Shu et al 125 loaded hollow mesoporous Prussian blue nanoparticles with lonidamine (which can inhibit the expression of HSPs) and DL-menthol (which acts as a plugging agent and controls the release of lonidamine) and encapsulated them with 4T1 cancer cell membrane to obtain biomimetic nano platform (PBLM@CCM NPs). The system was exposed to a 793 nm laser for 5 minutes, resulting in a signicant temperature increase of approximately 20 °C, whereas the PBS group exhibited only a modest increase of 3.6 °C.…”

Section: Phototherapymentioning

confidence: 99%

Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform

Guo,

Wang,

et al. 2024

RSC Adv.

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Section: Phototherapymentioning

confidence: 99%

Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform

Guo,

Wang,

et al. 2024

RSC Adv.

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“…[11] As an important component of inorganic materials, the first 2D nanomaterial (black phosphorus) was obtained by Novoselov et al in 2004, and has attracted considerable attention owing to its unique physical and chemical properties. [12,13] In biomedical applications, 2D nanomaterials have a number of advantages over other types of PTAs for NIR-II: a) large specific surface area conducive for surface modification and drug loading; [14][15][16] b) ultra-thin structures that can respond quickly to external stimuli such as NIR lasers and PH; [17][18][19] and c) excellent optical characteristics for optical imaging diagnosis. [20] In addition, different types of 2D nanomaterials have unique advantages for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Photothermal Therapy at Near‐Infrared‐II Based on 2D MXenes

Li,

Wang,

et al. 2023

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The use of photothermal therapy (PTT) with the near‐infrared II region (NIR‐II: 1000–1700 nm) is expected to be a powerful cancer treatment strategy. It retains the noninvasive nature and excellent temporal and spatial controllability of the traditional PTT, and offers significant advantages in terms of tissue penetration depth, background noise, and the maximum permissible exposure standards for skin. MXenes, transition‐metal carbides, nitrides, and carbonitrides are emerging inorganic nanomaterials with natural biocompatibility, wide spectral absorption, and a high photothermal conversion efficiency. The PTT of MXenes in the NIR‐II region not only provides a valuable reference for exploring photothermal agents that respond to NIR‐II in 2D inorganic nanomaterials, but also be considered as a promising biomedical therapy. First, the synthesis methods of 2D MXenes are briefly summarized, and the laser light source, mechanism of photothermal conversion, and evaluation criteria of photothermal performance are introduced. Second, the latest progress of PTT based on 2D MXenes in NIR‐II are reviewed, including titanium carbide (Ti3C2), niobium carbide (Nb2C), and molybdenum carbide (Mo2C). Finally, the main problems in the PTT application of 2D MXenes to NIR‐II and future research directions are discussed.

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Combined Photothermal Chemotherapy for Effective Treatment Against Breast Cancer in Mice Model

Chen,

Xiang,

Bao

et al. 2024

IJN

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Introduction Breast cancer ranks among the most prevalent cancers in women, characterized by significant morbidity, disability, and mortality. Presently, chemotherapy is the principal clinical approach for treating breast cancer; however, it is constrained by limited targeting capability and an inadequate therapeutic index. Photothermal therapy, as a non-invasive approach, offers the potential to be combined with chemotherapy to improve tumor cellular uptake and tissue penetration. In this research, a mesoporous polydopamine-coated gold nanorod nanoplatform, encapsulating doxorubicin (Au@mPDA@DOX), was developed. Methods This nanoplatform was constructed by surface coating mesoporous polydopamine (mPDA) onto gold nanorods, and doxorubicin (DOX) was encapsulated in Au@mPDA owing to π-π stacking between mPDA and DOX. The dynamic diameter, zeta potential, absorbance, photothermal conversion ability, and drug release behavior were determined. The cellular uptake, cytotoxicity, deep penetration, and anti-tumor effects were subsequently investigated in 4T1 cells. After that, fluorescence imaging, photothermal imaging and pharmacodynamics studies were utilized to evaluate the anti-tumor effects in tumor-bearing mice model. Results This nanoplatform exhibited high drug loading capacity, excellent photothermal conversion and, importantly, pH/photothermal dual-responsive drug release behavior. The in vitro results revealed enhanced photothermal-facilitated cellular uptake, drug release and tumor penetration of Au@mPDA@DOX under near-infrared irradiation. In vivo studies confirmed that, compared with monotherapy with either chemotherapy or photothermal therapy, the anti-tumor effects of Au@mPDA@DOX are synergistically improved. Conclusion Together with good biosafety and biocompatibility, the Au@mPDA@DOX nanoplatform provides an alternative method for safe and synergistic treatment of breast cancer.

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Robust boron nanoplatform provokes potent tumoricidal activities via inhibiting heat shock protein

Cited by 3 publications

References 37 publications

Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform

Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform

Recent Advances in Photothermal Therapy at Near‐Infrared‐II Based on 2D MXenes

Combined Photothermal Chemotherapy for Effective Treatment Against Breast Cancer in Mice Model

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