A large-scale CNC boring machine would not be complete without a column. The tortoise shell is chosen as the bionic prototype, and the column structure is optimized using the bionic optimization design approach, using the column of a thg6920 boring machine as the research object. The structural similarity between the completed turtle shell and the boring machine column is 0.796, according to the fuzzy method. The structural optimization and topological optimization of the column imitating turtle shell are carried out with the ANSYS Workbench, and the bionic column model is established, and then the static analysis and modal analysis are carried out. After bionic optimization and topology optimization, the weight of the column is reduced from 87061 kg to 82107 kg, the maximum stress is reduced to 3.8637 MPa, the maximum stress is reduced by 28.9% compared with the original column, and the specific stiffness and specific strength are increased by 20.65% and 29.4%, respectively. The column structure has also achieved good optimization results in stiffness, strength, and stability.