An accepted autopilot control architecture for fixed-wing unmanned aerial vehicles (UAVs) is the so-called cascaded loop closure, in which inner velocity loops and outer position loops are successively closed with proportionalintegral-derivative (PID) controllers. This architecture has become so standard that popular open-source autopilots (e.g. ArduPilot, PX4) implement it in their codes. Despite its popularity, such architecture cannot adequately cope with the inevitable uncertainty in the UAV dynamics. In this work we present a "plug-and-play" adaptive module integrated in standard cascaded autopilot architectures, so as to can guarantee adaptation in the presence of uncertainty. The proposed module is analyzed and tested in a software-in-the-loop environment for an ArduPilot-based autopilot. The tests show that, in the presence of uncertainties occurring during flight, the proposed adaptation module outperforms the original autopilot as well as non-adaptive autopilots.