2021
DOI: 10.3390/nano11030719
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Robust Copper Metal–Organic Framework-Embedded Polysiloxanes for Biomedical Applications: Its Antibacterial Effects on MRSA and In Vitro Cytotoxicity

Abstract: Polysiloxanes (PSs) have been widely utilized in the industry as lubricants, varnishes, paints, release agents, adhesives, and insulators. In addition, their applications have been expanded to include the development of new biomedical materials. To modify PS for application in therapeutic purposes, a flexible antibacterial Cu-MOF (metal–organic framework) consisting of glutarate and 1,2-bis(4-pyridyl)ethane ligands was embedded in PS via a hydrosilylation reaction of vinyl-terminated and H-terminated PSs at 25… Show more

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Cited by 29 publications
(18 citation statements)
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“…For example, Lee and colleagues previously developed a series of robust MOFs with a 3D framework and high surface area volume ratio, showing excellent antibacterial activity against Escherichia coli and Staphylococcus aureus. This is highly relevant to the current work [18,19]. Ma and coworkers synthesized three iron-based MOFs for adsorption of a typical volatile organic compound, toluene [20].…”
Section: Introductionmentioning
confidence: 90%
“…For example, Lee and colleagues previously developed a series of robust MOFs with a 3D framework and high surface area volume ratio, showing excellent antibacterial activity against Escherichia coli and Staphylococcus aureus. This is highly relevant to the current work [18,19]. Ma and coworkers synthesized three iron-based MOFs for adsorption of a typical volatile organic compound, toluene [20].…”
Section: Introductionmentioning
confidence: 90%
“…The main mechanisms of NP antibacterial effects include an impairment in metabolism or bacterial integrity (CuNPs), replication and transcription disruption, tRNA, ATPases, membrane-bound enzymes and biofilm inhibition, protein denaturation (AgNPs), and reactive oxygen species (ROS) production [ 64 , 65 , 66 ]. Various NPs such as silver (Ag), gold (Au), and lower-cost NPs such as nickel (Ni), titanium-oxide, (TiO), zinc oxide (ZnO), silica (SiO2), and bismuth (Bi) NPs have deciphered efficient bactericidal effects against MRSA in vitro and in vivo [ 67 , 68 , 69 , 70 , 71 ]. Various methods of NP delivery to cells for antibacterial activity include polymeric NPs, liposomes, carbon NPs, and metal or metal-oxide NPs.…”
Section: Nanoparticle Applications To Combat Mrsamentioning
confidence: 99%
“…However, in the design of therapeutics, minimal cytotoxicity towards healthy cells is desired. This is achieved by linking copper with biocompatible organic templates, such as proteins, via coordination bonds [ 9 ].…”
Section: Introductionmentioning
confidence: 99%