Robust design of countercurrent adsorption separation processes: 2. Multicomponent systems

Mazzotti, Marco; Storti, Giuseppe; Morbidelli, Massimo

doi:10.1002/aic.690401107

Cited by 103 publications

(98 citation statements)

References 9 publications

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“…However, others used the equilibrium theory and neglected mass transfer resistances and axial mixing (Storti et al, 1989a(Storti et al, , 1993Mazzotti et al, 1994).…”

Section: Modeling Of a Simulated Moving Bedmentioning

confidence: 99%

Separation of 1,1′-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed

Pais

Loureiro

Rodrigues

1997

Chemical Engineering Science

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Abstract--The chromatographic separation of 1,1'-bi-2-naphthol enantiomers with 3,5-dinitrobenzoyl phenylglycine bonded to silica gel stationary phases is studied. Continuous chromatography in simulated moving bed (SMB) is analyzed by modeling, simulation and operation of a SMB pilot unit Licosep 12-26 from Separex (France).A model for the prediction of the cyclic steady-state performance of the SMB is developed based on the analogy with the true moving bed (TMB). The model assumes axial dispersion flow for the liquid phase, linear driving force (LDF) approximation for intraparticle mass transfer rate and takes into account multicomponent adsorption equilibria.The SMB package allows the simulation of the pilot unit. The effect of operating variables (switching time, extract and feed flow rates, section length) and number of mass transfer units on the SMB performance is analyzed. The SMB performance is characterized by purity, recovery, solvent consumption and adsorbent productivity. The package also allows the simulation of the dynamic evolution of internal profiles for the transient operation of a TMB. The operation of the SMB pilot unit was carried out for the separation of racemic mixtures of bi-naphthol enantiomers. Using a 8-column configuration purities as high as 94.5% of the more retained species in the extract and 98.9% of the less retained species in the raffinate were obtained.

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“…However, others used the equilibrium theory and neglected mass transfer resistances and axial mixing (Storti et al, 1989a(Storti et al, , 1993Mazzotti et al, 1994).…”

Section: Modeling Of a Simulated Moving Bedmentioning

confidence: 99%

Separation of 1,1′-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed

Pais

Loureiro

Rodrigues

1997

Chemical Engineering Science

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“…Following the work of Storti et al (1993) and Mazzotti et al (1994), a local-equilibrium, four-section TCC adsorption unit will be employed to model a SMB process. As illustrated in Figure 1, the pure fluid streams connecting the sections will be identified by alphabetical superscripts; the composite solid streams between sections will be indicated by Greek letters; and the TCC sections will be designated by numerical symbols, In addition, capital letters D, F , E , and R will be used to identify the desorbent, the feed, the extract, and the raffinate streams, respectively.…”

Section: Theoretical Backgroundsmentioning

confidence: 99%

“…For such purposes, a simple equilibrium model may be of great value. A steady-state, local-equilibrium, true countercurrent (TCC) adsorption model was employed by Storti et al (1989Storti et al ( , 1993Storti et al ( , 1995 and Mazzotti et al (1994Mazzotti et al ( , 1996Mazzotti et al ( , 1997 in a series of efforts to study the SMB process. The purpose was to obtain the most important design rules with a simple but adequate model.…”

Section: Introductionmentioning

confidence: 99%

“…The results were then checked against the complete separation criteria. To bypass the tedious calculations, a shortcut method that treated a multicomponent feed as a pseudobinary system was proposed (Mazzotti et al, 1994). However, the prediction of the short cut method was not very accurate.new technique to solve the equilibrium model is demonstrated, with which explicit expressions were obtained to outline the complete separation region on (m2, m,) plane.…”

mentioning

confidence: 99%

“…However, for a multicomponent system, this region had to be determined by trial and error (Mazzotti et al, 1994(Mazzotti et al, , 1996. Specifically, a system of constrained nonlinear equations had to be solved for each point on the ( m 2 , m,) plane.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Complete separation conditions for a local equilibrium TCC adsorption unit

Chiang

1998

AIChE Journal

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Adsorption, Liquid Separation

Gembicki¹,

Oroskar²,

Johnson³

2002

Kirk-Othmer Encyclopedia of Chemical Technology

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Nearly every chemical manufacturing operation requires the use of separation processes to recover and purify the desired product. Liquid‐phase adsorption has long been used for the removal of contaminants present at low concentrations in process streams such as in deodorization of water, decolorization of sugar, and ion exchange of fermentation broth. Liquid‐phase simulated moving bed (SMB) processes are being increasingly used for bulk separation of a whole range of molecules whose molecular properties are very similar. Examples are p ‐xylene from C 8 aromatics, normal paraffins from iso‐paraffins, fructose from glucose, and chiral molecules in the pharmaceutical industry. When it comes to the separation of close boiling molecules, SMB processes generally provide a better alternative to other conventional means of separation from both operating and capital costs point of view. This article reviews the application of liquid‐phase adsorption processes in the hydrocarbon, industrial chemicals, food, and pharmaceutical industry. Special emphasis is given to the class of processes referred to as SMB processes including fundamental SMB principles , and the general applicability and guidelines for SMB design. The paper also illustrates several examples of SMB applications in the petrochemical industry and its recent growth in the pharmaceutical and biotech industry.

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Robust design of countercurrent adsorption separation processes: 2. Multicomponent systems

Abstract: The adsorption separation of a multicomponent mixture in a four-section countercurrent separation unit is analyzed. A

Cited by 103 publications

References 9 publications

Separation of 1,1′-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed

Separation of 1,1′-bi-2-naphthol enantiomers by continuous chromatography in simulated moving bed

Complete separation conditions for a local equilibrium TCC adsorption unit

Adsorption, Liquid Separation

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