Robust determination of the fibre orientation distribution in diffusion MRI: Non-negativity constrained super-resolved spherical deconvolution

Tournier, Jacques‐Donald; Calamante, Fernando; Connelly, Alan

doi:10.1016/j.neuroimage.2007.02.016

Cited by 2,013 publications

(2,029 citation statements)

References 34 publications

Supporting

Mentioning

1,925

Contrasting

Unclassified

Order By: Relevance

“…Each streamline was propagated using the second‐order integration over fiber orientation distributions (iFOD2) probabilistic tractography algorithm (Tournier, Calamante, & Connelly, 2010). Streamlines were guided by fiber orientations inferred using spherical deconvolution with a maximum harmonic order ( l max ) of 4 (Tournier, Calamante, & Connelly, 2007). Propagation was terminated if either a minimum angle threshold of 45° was violated or the streamline propagated beyond the white matter mask.…”

Section: Methodsmentioning

confidence: 99%

Minimum spanning tree analysis of the human connectome

Dellen

Sommer

Bohlken

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

One of the challenges of brain network analysis is to directly compare network organization between subjects, irrespective of the number or strength of connections. In this study, we used minimum spanning tree (MST; a unique, acyclic subnetwork with a fixed number of connections) analysis to characterize the human brain network to create an empirical reference network. Such a reference network could be used as a null model of connections that form the backbone structure of the human brain. We analyzed the MST in three diffusion‐weighted imaging datasets of healthy adults. The MST of the group mean connectivity matrix was used as the empirical null‐model. The MST of individual subjects matched this reference MST for a mean 58%–88% of connections, depending on the analysis pipeline. Hub nodes in the MST matched with previously reported locations of hub regions, including the so‐called rich club nodes (a subset of high‐degree, highly interconnected nodes). Although most brain network studies have focused primarily on cortical connections, cortical–subcortical connections were consistently present in the MST across subjects. Brain network efficiency was higher when these connections were included in the analysis, suggesting that these tracts may be utilized as the major neural communication routes. Finally, we confirmed that MST characteristics index the effects of brain aging. We conclude that the MST provides an elegant and straightforward approach to analyze structural brain networks, and to test network topological features of individual subjects in comparison to empirical null models.

show abstract

Section: Methodsmentioning

confidence: 99%

Minimum spanning tree analysis of the human connectome

Dellen

Sommer

Bohlken

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Constrained spherical deconvolution (CSD) (Tournier et al, 2007) was used to model multiple fibre orientations, and probabilistic tracking (Behrens et al, 2003) was performed using the 2 nd order integration over fibre orientation distributions (iFOD2) algorithm . Whole-brain (or wholephantom) tracking was performed by randomly seeding throughout the brain or throughout the numerical phantom (i.e.…”

Section: Fibre-trackingmentioning

confidence: 99%

“…seed points were randomly defined in continuous space covering the whole brain or phantom) using the following relevant parameters: 1 mm step-size, maximum angle between steps = 45º, 3 FOD samples/step, any track with length < 10 mm (for the in vivo data) or < 4 mm (for the in silico data) was discarded, termination criteria: exit the brain (or the numerical phantom) or when the CSD fibre-orientation distribution amplitude was < 0.1. The primary parameter of interest in CSD is the maximum harmonic order lmax (which determines the 'sharpness' of the fibre orientation distributions) (Tournier et al, 2004;Tournier et al, 2007;Tournier et al, 2008); lmax = 10 (for the in vivo data) and 8 (for the in silico data) were employed in this study.…”

Section: Fibre-trackingmentioning

confidence: 99%

Track density imaging (TDI): Validation of super resolution property

et al. 2011

Self Cite

View full text Add to dashboard Cite

“…This technique theoretically provides an advantage over traditional diffusion tensor imaging (DTI) in the study of intertwined and crossing fiber tracts (Frank, 2002; Tournier, Calamante, & Connelly, 2007; Tournier, Calamante, Gadian, & Connelly, 2004) which are common among cerebellar peduncular tracts. Although several techniques to assess white matter development have been developed in addition to diffusion MR tractography (Ball et al., 2013; O'Muircheartaigh et al., 2014), advantages of diffusion tractography include the detection of three‐dimensional fiber bundle pathways.…”

Section: Introductionmentioning

confidence: 99%

High‐angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults

Levman

Lim

et al. 2016

Brain and Behavior

View full text Add to dashboard Cite

IntroductionMany neurologic and psychiatric disorders are thought to be due to, or result in, developmental errors in neuronal cerebellar connectivity. In this connectivity analysis, we studied the developmental time‐course of cerebellar peduncle pathways in pediatric and young adult subjects.MethodsA cohort of 80 subjects, newborns to young adults, was studied on a 3T MR system with 30 diffusion‐weighted measurements with high‐angular resolution diffusion imaging (HARDI) tractography.ResultsQualitative and quantitative results were analyzed for age‐based variation. In subjects of all ages, the superior cerebellar peduncle pathway (SCP) and two distinct subpathways of the middle cerebellar peduncle (MCP), as described in previous ex vivo studies, were identified in vivo with this technique: pathways between the rostral pons and inferior‐lateral cerebellum (MCP cog), associated predominantly with higher cognitive function, and pathways between the caudal pons and superior‐medial cerebellum (MCP mot), associated predominantly with motor function.DiscussionOur findings showed that the inferior cerebellar peduncle pathway (ICP), involved primarily in proprioception and balance appears to have a later onset followed by more rapid development than that exhibited in other tracts. We hope that this study may provide an initial point of reference for future studies of normal and pathologic development of cerebellar connectivity.

show abstract

Robust determination of the fibre orientation distribution in diffusion MRI: Non-negativity constrained super-resolved spherical deconvolution

Cited by 2,013 publications

References 34 publications

Minimum spanning tree analysis of the human connectome

Minimum spanning tree analysis of the human connectome

Track density imaging (TDI): Validation of super resolution property

High‐angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults

Contact Info

Product

Resources

About