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REPORT DATE
01-11-20072. REPORT TYPE
Annual Summary
DATES COVERED
PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERJohns Hopkins University Baltimore, MD 21218-2686
SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)
U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012
SPONSOR/MONITOR'S REPORT NUMBER(S)
DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited
SUPPLEMENTARY NOTESOriginal contains colored plates: ALL DTIC reproductions will be in black and white.
ABSTRACTFavorable outcome in prostate brachytherapy critically depends on the accurate placement of radioactive sources in their planned locations. Unfortunately, there is variety of mechanical factors that cause the seeds to divert from their planned locations. While this problem has been known to brachytherapists, current technology does not allow for reliable localization of the implanted sources, thereby prohibiting the prediction and modification of seed distribution intra-operatively. The Research Objective of the proposal is to develop and evaluate ex-vivo a method for intra-operative localization of the implanted seeds in relation to the prostate, to facilitate in-situ dosimetric optimization and exit dosimetry. In particular, we will: [1] Registration of Ultrasound to Fluoroscopy (RUF): Develop methods for reconstruction of seed implants from X-ray fluoroscopy and spatially register them to the prostate anatomy identified in TRUS [2] System Integration: Integrate the above methods in a software package and link it with the FDA-approved CMS Interplant® prostate brachytherapy system to enable in-situ dosimetry calculation [3] Experimental Validation: Evaluate the performance of the RUF system on phantoms and pre-recorded patient data.
SUBJECT TERMSProstate Brachytherapy, X-ray reconstruction, C-arm, TRUS
Progress Report Summary Project Year 2 (2006 -2007)A INTRODUCTION For several decades, the definitive treatment for low and medium risk prostate cancer was radical prostatectomy or external beam radiation ther...