Actuator faults, which are common in industrial processes, can make the controller fail to achieve the desired control objectives, which may lead to the degradation of control performance. In order to solve this problem, this paper proposes a predictive functional control based on genetic algorithm optimization. Firstly, an extended dimension discrete switched model is constructed, which consists of a state difference variable, tracking error and a new state variable including tracking error. In this model, the performance index function based on a genetic optimization algorithm is selected, and its parameters are adjusted and the controller is designed. Then, under the obtained control law, the switching signal is designed and the range of uncertainty caused by the actuator fault is given to realize the robustness of the system. At the same time, the corresponding robustly sufficient conditions are presented. The advantage of this design is to avoid the disadvantages of manually adjusting the performance parameters, and the system has good tracking performance. Finally, taking the typical injection molding process of chemical production process as an example, the speed and pressure parameters are controlled, and compared with the traditional control method, the effectiveness and feasibility of the proposed method are verified. INDEX TERMS Chemical industry processes, partial actuator faults, genetic-algorithm-optimization design, predictive functional control