2010
DOI: 10.1177/1471082x0801000304
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Robust frailty modelling using non-proportional hazards models

Abstract: Abstract. Correlated survival times can be modelled by introducing a random effect, or frailty component, into the hazard function. For multivariate survival data we extend a non-PH model, the generalized time-dependent logistic survival model, to include random effects. The hierarchical-likelihood procedure, which obviates the need for marginalization over the random effect distribution, is derived for this extended model and its properties discussed. The extended model leads to a robust estimation result for… Show more

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Cited by 9 publications
(7 citation statements)
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“…Prior to this solution, the GTDL model was used successfully with λ 0 = 1, when it was designated the TDL model. However, today, the Gamma frailty extension is preferred (Blagojevic et al 2003;MacKenzie and Ha 2007;Ha and MacKenzie 2010).…”
Section: Remarkmentioning
confidence: 99%
“…Prior to this solution, the GTDL model was used successfully with λ 0 = 1, when it was designated the TDL model. However, today, the Gamma frailty extension is preferred (Blagojevic et al 2003;MacKenzie and Ha 2007;Ha and MacKenzie 2010).…”
Section: Remarkmentioning
confidence: 99%
“…Due to the complexity of the GTDL-RWLF model, the regularity conditions are not easy to verify analytically. In this case, simulation studies are required; see, for example, Ha and MacKenzie (2010), Ortega et al (2015), and Barriga et al (2019). Following this idea, in the next section, we describe a simulation study performed to investigate whether the usual asymptotic properties of the ML estimators hold.…”
Section: A L G O R I T H M 1 Generator Of Random Times From the Gtdl-rwlf Modelmentioning
confidence: 99%
“…In order to make inferences on frailty models, we have some options. For instance, obtaining the marginal hazard and reliability functions and using the traditional likelihood function; or choosing other methods that obviate the need for marginalization, such as the h-likelihood approach proposed by Ha et al [48] and used in [49]. This paper considers the marginal hazard and reliability functions.…”
Section: B Gtdl Frailty Modelmentioning
confidence: 99%