In order to develop and implement the laws piloting for an aircraft, flights validation will be necessary. This could in fact be done, in a first step, by using flight simulators. In this work, we choose the predator virtual model flying in Microsoft TM flight simulator (MSFS) and we propose the procedure of controlling its attitude. We send the adaptive integral high-order sliding mode (AIHOSM) inputs piloting control. This work is a realtime virtual simulation. For the AIHOSM controller, we propose the gain adaptation for reduction of chattering phenomena and possibility to control the aircraft presented by the uncertain nonlinear systems in which the uncertainties have unknown bounds. This technique is more robust and simpler to implement than the quaternion one and only needs the information about the sliding mode surface.