2023
DOI: 10.1101/2023.06.24.546224
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Robust Homeostasis of Cellular Cholesterol via Antithetic Integral Control

Abstract: Although cholesterol is essential for cellular viability and proliferation, it is highly toxic in excess. The concentration of cellular cholesterol must therefore be maintained within tight tolerances and is thought to be subject to a stringent form of homeostasis known as Robust Perfect Adaptation (RPA). While much is known about the cellular signalling interactions involved in cholesterol regulation, the specific chemical reaction network structures that might be responsible for the robust homeostatic regula… Show more

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