2023
DOI: 10.1002/cti2.1456
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Robust immunity to influenza vaccination in haematopoietic stem cell transplant recipients following reconstitution of humoral and adaptive immunity

Abstract: Objectives Influenza causes significant morbidity and mortality, especially in high‐risk populations. Although current vaccination regimens are the best method to combat annual influenza disease, vaccine efficacy can be low in high‐risk groups, such as haematopoietic stem cell transplant (HSCT) recipients. Methods We comprehensively assessed humoral immunity, antibody landscapes, systems serology and influenza‐specific B‐cell responses, together with their phenotypes and isotypes, to the inactivated influenza … Show more

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Cited by 4 publications
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“…The adjuvanted vaccine contains an MF59 adjuvant, which accentuates the immune response. There are currently no safety studies in SLE patients with these vaccines, but high-dose quadrivalent influenza vaccine and adjuvanted trivalent vaccines have higher immunogenicity in other immunocompromised groups [38–40]. Rheumatoid arthritis patients were more likely to seroconvert with high-dose trivalent vaccine compared to standard dose quadrivalent vaccine [41].…”
Section: Special Implications Of Influenza Vaccination In Systemic Lu...mentioning
confidence: 99%
“…The adjuvanted vaccine contains an MF59 adjuvant, which accentuates the immune response. There are currently no safety studies in SLE patients with these vaccines, but high-dose quadrivalent influenza vaccine and adjuvanted trivalent vaccines have higher immunogenicity in other immunocompromised groups [38–40]. Rheumatoid arthritis patients were more likely to seroconvert with high-dose trivalent vaccine compared to standard dose quadrivalent vaccine [41].…”
Section: Special Implications Of Influenza Vaccination In Systemic Lu...mentioning
confidence: 99%