In the industrial and military sector, work activities are required transporting or supporting heavy loads manually, affecting this the human spinal column due to the weight of the loads or the repetition of this labor. In this regard, the use of force-enhancing exoskeletons is a potential solution to this issue. Therefore, this article summarizes the state of the art in relevant contributions to structural design, control systems, actuators, and performance metrics to evaluate the proper functioning of exoskeletons used for load support and transfer. This is essential to address current and new open problems in these applications, and this includes reducing the metabolic cost and enhancing the loading force in exoskeletons, in which challenges such as structural design and kinetic interactions between the human and the robot are presented. The systematic review of the strategies found in the literature helps addressing these challenges in an orderly way. The proposal of some alternative solutions could help to solving some of the challenges mentioned above, as well as further research to improve the design of these devices is necessary.