Gasoline is one of the most recognized products of the petroleum industry due to its use as a liquid fuel worldwide. As a result, it is of great importance to accurately determine the properties of gasoline, so as to evaluate its quality. In this article, an effective mathematical and predictive strategy, namely least squares support vector machines (LSSVM) is applied to predict some gasoline properties, viz. specific gravity (SG), motor octane number (MON), research octane number (RON), and Reid vapor pressure (RVP). A comprehensive error analysis is also undertaken to compare the values predicted from the model with actual data which enables one to evaluate the performance of the model developed in this study. The results indicate that the model developed has reasonable accuracy and prediction capability. The correlation indices, R 2 , are 0.990, 0.933, 0.955, and 0.920 for SG, MON, RON, and RVP, respectively.