Robust reference intervals for Liver function test (LFT) analytes in newborns and infants

Melkie, Mulugeta; Yigeremu, Mahilet; Nigussie, Paulos; Asrat, Shawel; Gebreegziabher, Tatek; Teka, Tilahun A.; Kinde, Samuel

doi:10.1186/1756-0500-5-493

Cited by 13 publications

(16 citation statements)

References 23 publications

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“…Alkaline phosphatase followed a similar trend in being relatively elevated in the first few months of life. The range we report is similar to that of other infants [29,30] and is several-fold higher than that of adult concentrations (32-91 U/L; Beckman Coulter). We noted several episodes of markedly elevated alkaline phosphatase (N 1000 U/L; hyperphosphatasemia), particularly in children 9 mo or older.…”

Section: Discussionsupporting

confidence: 84%

Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada

Gallo

Comeau

Sharma

et al. 2014

Clinical Biochemistry

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Section: Discussionsupporting

confidence: 84%

Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada

Gallo

Comeau

Sharma

et al. 2014

Clinical Biochemistry

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“…When similar studies in the literature are examined, the most important point missed is analyzing the tests one by one in the outliers or RI calculation [17,20]. In the related studies, we think that one of the reasons of the difference especially in the region-based comparisons could be not analyzing the correlations between tests.…”

Section: Discussionmentioning

confidence: 93%

“…Therefore, as in other studies in the literature, tests should be evaluated by considering together, not separately [1][2][3][4][5][6][7][8]16,17,20]. In our study, RIs of the individuals aged 18-70 were identified by a new Brought to you by | New York University Bobst Library Technical Services Authenticated Download Date | 10/8/15 9:48 AM approach.…”

Section: Discussionmentioning

confidence: 98%

Comparison of classical and clustering based reference interval calculations for Aspartate Aminotransferase, Alanine Aminotransferase and Gamma-Glutamyl Transferase in serum / Aspartat Aminotransferaz, Alanin Aminotransferaz ve Gama Glutamil Transferaz serum için klasik ve kümelemeye dayalı referans aralık hesaplamalarının karşılaştırılması

Coşgun

Topçu²,

Lâleli³

2015

Turkish Journal of Biochemistry

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Objective: There are fixed rules applied to determine the reference intervals (RIs) of the biochemical tests. However, these rules lack for identifying subgroups within the reference population. Therefore, we suggest the clustering method, which determines the sub-groups by taking the correlations between the variables into account in the RIs calculations. In our study, it is aimed to compare the results of the RIs based on the clusters analysis with the results of the conventional method.Methods: The individuals who applied Ankara Düzen Laboratory for the check-up with normal Ultra Sono Grafi (USG) in 2012-2014 and who have had Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and G-Glutamyl Transferase (GGT); (U/L) results were included in this study. We have excluded the repeated applies of patients, only analyzed the first apply to the laboratory. Reference individuals are composed of 883 people. (610 male, 273 female, 18-70 years). Non-parametric methods were used to determine reference intervals. Fuzzy C-Means clustering method was used to identify sub-groups.Results: AST, ALT, GGT measurements for all of the check-up individuals were determined by non-parametric method for the three subgroups specified after the Fuzzy-C-Means clustering method and the entire group. According to the reference intervals obtained, the third sub-cluster derived from the group intended to be used as the reference population was observed as a cluster that is narrower, and has similar properties of the actual reference population. However, when the correlations between the tests in the sub-groups are considered, the correlations between GGT-ALT-AST have been observed to be higher while the correlation level between ALT-AST in the group proposed as a real reference population does not change.Conclusion: In the reference limit studies, instead of the determination of the reference interval for a single group designated as the reference population, we think that, the subgroups which are homogeneous within itself, heterogeneous between themselves should be set in in this group. In determining multiple sub-groups, the relationship between more than one test need to be taken into consideration, and the effect of clustering should be investigated.Özet: Amaç: Biyokimyasal testlerin referans aralıklarının belirlenmesi için kullanılan sabit kurallar bulunmaktadır. Ancak bu kuralların referans popülasyon içerisindeki alt grupların tanımlanmasında eksikleri bulunmaktadır. Bu nedenle RIs hesaplamasında değişkenler arasındaki korelasyonları göz önüne alarak alt grupları belirleyen küme-leme yöntemini önermekteyiz. Çalışmamızda kümele analizine dayalı referans aralıklar ile klasik yöntemin sonuçlarının karşılaştırılması amaçlanmıştır.

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“…The inclusion and exclusion criteria and data collection and analysis were described in our recent publication [1]. Cord blood (from newborns) and venous blood samples (from infants) were collected and analyzed using direct ISE analyzer (AVL 9181, Roche diagnostics GmbH, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…This work is an extension of the study that we have recently published [1]. A test for electrolytes mostly includes the measurement of sodium (Na + ), potassium (K + ) and chloride (Cl - ) ions.…”

Section: Introductionmentioning

confidence: 99%

Establishing reference intervals for electrolytes in newborns and infants using direct ISE analyzer

et al. 2013

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BackgroundTo generate clinically applicable reference intervals (RIs) for commonly requested electrolytes in Ethiopian newborns and infants that can help in early detection, close monitoring and correction of electrolyte abnormalities. Cord blood (from newborns, n = 60) and venous blood samples (from infants, n = 57) were collected and analyzed using direct ISE analyzer, AVL (9181). MedCalc® software was applied to determine the robust upper and lower end points covering 95% of the reference values of each electrolyte with respective 90% CIs.FindingsThis is an extension report of our recent study; and hence is resulted from the same data source. The level of Na+ and K+ showed difference in newborns and infants even though combined RIs were suggested by the Haris and Boyd rule as 126–143 mmol/l and 4.0-7.9 mmol/l respectively. However, Cl- values failed to show such a difference and thus a combined RI was determined to be 100–111 mmol/l. Almost all maternal, neonatal and infantile factors were not able to affect the values of the electrolytes.ConclusionCombined RIs are suggested for the interpretation of electrolyte values in newborns and infants without taking the effect of maternal, neonatal and infantile factors into account. Since the RIs were different from previously reported values, it will be appropriate to apply such RIs for the interpretation of electrolyte values in Ethiopian pediatric population.

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Robust reference intervals for Liver function test (LFT) analytes in newborns and infants

Cited by 13 publications

References 23 publications

Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada

Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada

Establishing reference intervals for electrolytes in newborns and infants using direct ISE analyzer

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