Abstract. The problem of synthesizing feedback controllers that perform sensing and actuation actions on non-uniform and uncertain discrete time domains is considered. This class of problems is relevant to many application domains. For instance, in engine control a heterogenous and, to some extent, uncertain event-driven time domain is due to the behavior of the 4-stroke internal combustion engine, with which the controller has to synchronize to operate properly. Similar problems arise also in standard discrete-time control systems when considering the behavior of the system with controller implementation and communication effects. The design problem is formalized in a hybrid system framework; synthesis and verification methods, based on robust stability and robust performance results, are presented. The effectiveness of the proposed methods is demonstrated in an engine control application.