Robust topology optimization of biodegradable composite structures under uncertain degradation rates

Zhang, Heng; Takezawa, Akihiro; Ding, Xuanming; Zhang, Xiaopeng; Xu, Shipeng; Li, Hao; NOZAWA, Shuya; Nishiwaki, Shinji

doi:10.1016/j.compstruct.2022.115593

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…For instance, it is usually required that bone scaffolds have a slow degradation in the early stage to maintain the high mechanical strength and then fast degradation . Alternatively, when the condition of a patient treated with the citrate-based drug-eluting stent (DES) suddenly deteriorates, there is an urgent need to accelerate the degradation of the matrix to quickly release the drug for inhibition, or perhaps after finishing a given task, the citrate-based bioelectronic devices are required to be rapidly degraded to avoid the risks to the body due to their long-term retention . Notably, the degradation rates of these biodegradable implants highly depend on their matrix materials (citrate-based polymers) generally. − However, the existing citrate-based polymers can only be degraded passively, resulting in these fabricated citrate-based implants hardly being regulated to their degradation rates as required during clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Citrate-Based Polyester Elastomer with Artificially Regulatable Degradation Rate on Demand

Wan

Liang

et al. 2023

Biomacromolecules

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Citrate-based polymers are commonly used to create biodegradable implants. In an era of personalized medicine, it is highly desired that the degradation rates of citrate-based implants can be artificially regulated as required during clinical applications. Unfortunately, current citrate-based polymers only undergo passive degradation, which follows a specific degradation profile. This presents a considerable challenge for the use of citratebased implants. To address this, a novel citrate-based polyester elastomer (POCSS) with artificially regulatable degradation rate is developed by incorporating disulfide bonds (S−S) into the backbone chains of the crosslinking network of poly-(octamethylene citrate) (POC). This POCSS exhibits excellent and tunable mechanical properties, notable antibacterial properties, good biocompatibility, and low biotoxicity of its degradation products. The degradation rate of the POCSS can be regulated by breaking the S−S in its crosslinking network using glutathione (GSH). After a period of subcutaneous implantation of POCSS scaffolds in mice, the degradation rate eventually increased by 2.46 times through the subcutaneous administration of GSH. Notably, we observed no significant adverse effects on its surrounding tissues, the balance of the physiological environment, major organs, and the health status of the mice during degradation.

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Section: Introductionmentioning

confidence: 99%

Citrate-Based Polyester Elastomer with Artificially Regulatable Degradation Rate on Demand

Wan

Liang

et al. 2023

Biomacromolecules

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Uncertainty quantification and robust shape optimization of acoustic structures based on IGA BEM and polynomial chaos expansion

Lin,

Zheng,

Zhang

et al. 2024

Engineering Analysis with Boundary Elements

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Topology and orientation optimization of fiber-reinforced materials under fiber manufacturing uncertainty

NOZAWA

Zhang

ZHANG

et al. 2022

Transactions of the JSME (In Japanese)

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Fiber-reinforced composites are currently considered engaging materials by engineers and researchers in automobile, aerospace, robotics, and other related industries and scholars in academics due to their superior mechanical properties.Using the materials as structural materials allows engineers to make lightweight but high-stiff mechanical structures happen in reality. By adopting a structural optimization methodology, they can explore further and bring out the mechanical properties of composites as much as possible to design innovative composites structures. Based on this background, it has already been a hot research topic to establish a method for concurrent optimization of topology and fiber orientation in the structural optimization research field. This optimization method will be more effective in the real world by considering uncertainties that engineers commonly encounter. However, anisotropic topology optimization researches on this motivation are very rare. In the present work, we propose a robust topology and orientation optimization methodology accounting for fiber manufacturing uncertainty, namely orientation uncertainty. The proposed method is built upon the Phase Field and the Method of Moving Asymptotes based SIMP type topology optimization and EOLE-PCE uncertainty quantification. Numerical analysis is done by the Finite Element Method. The effectiveness of the proposed method is validated through the compliance minimization problem and the fundamental eigenfrequency maximization problem.

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Robust topology optimization of biodegradable composite structures under uncertain degradation rates

Cited by 3 publications

References 56 publications

Citrate-Based Polyester Elastomer with Artificially Regulatable Degradation Rate on Demand

Citrate-Based Polyester Elastomer with Artificially Regulatable Degradation Rate on Demand

Uncertainty quantification and robust shape optimization of acoustic structures based on IGA BEM and polynomial chaos expansion

Topology and orientation optimization of fiber-reinforced materials under fiber manufacturing uncertainty

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