Robustness of indispensable nodes in controlling protein-protein interaction network

Zhang, Xizhe; Wang, Huaizhen; Yang, Yunyi

doi:10.48550/arxiv.1609.02637

2016

DOI: 10.48550/arxiv.1609.02637

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Robustness of indispensable nodes in controlling protein-protein interaction network

Xizhe Zhang¹,

Huaizhen Wang²,

Yunyi Yang³

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2020

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Cited by 1 publication

References 21 publications

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Response of Lyapunov exponents to diffusion state of biological networks

Altuntaş¹,

Gök²,

Koçal³

2020

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The topologies of protein-protein interaction networks are uncertain and noisy. The network topology determines the reliability of computational knowledge acquired from noisy networks and can impose the deterministic and non-deterministic character of the resulting data. In this study, we analyze the effect of the network topology on Lyapunov exponents and its relationship with network stability. We define the methodology to convert the network data into signal data and obtain the Lyapunov exponents for a variety of networks. We then compare the Lyapunov exponent response and the stability results. Our technique can be applied to all types of network topologies as demonstrated with our experiments, conducted on both synthetic and real networks from public databases. For the first time, this article presents findings where Lyapunov exponents are evaluated under topological mutations and used for network analysis. Experimental results show that Lyapunov exponents have a strong correlation with network stability and both are correlatively affected by the network model. Hence we develop a novel coefficient, termed LEC, to measure the robustness of biological networks. LEC can be applied to real or synthetic biological networks rapidly. Results are a striking indication that the Lyapunov exponent is a potential candidate measure for network analysis.

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Response of Lyapunov exponents to diffusion state of biological networks

Altuntaş¹,

Gök²,

Koçal³

2020

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Robustness of indispensable nodes in controlling protein-protein interaction network

Cited by 1 publication

References 21 publications

Response of Lyapunov exponents to diffusion state of biological networks

Response of Lyapunov exponents to diffusion state of biological networks

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