Robustness of the hypoxic response: Another job for miRNAs?

Ezcurra, Ana Laura De Lella; Bertolin, Agustina P.; Melani, Mariana; Wappner, Pablo

doi:10.1002/dvdy.23865

Cited by 9 publications

(3 citation statements)

References 86 publications

(104 reference statements)

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“…In this way, miR‐155 promotes the resolution of hypoxia inducible factor‐1α activity in hypoxia . A similar phenomenon was most recently described for miR‐210 , which controls host responses to hypoxia by promoting the induction of autophagic pathways but also by targeting hypoxia‐inducible factor‐1α, thereby limiting the duration of the hypoxic reaction .…”

Section: Mirnas In Periodontitis and Periodontitis‐related Mechanismssupporting

confidence: 64%

Mini but mighty: microRNAs in the pathobiology of periodontal disease

Kebschull¹,

Papapanou²

2015

Periodontology 2000

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microRNAs (miRNAs) are a family of small, non-coding RNA molecules that negatively regulate protein expression by either inhibiting the initiation of the translation of mRNA, or by inducing the degradation of mRNA molecules. Accumulating evidence suggests that miRNA-mediated repression of protein expression is of paramount importance in a broad range of physiologic and pathologic conditions. In particular, miRNA-induced dysregulation of molecular processes involved in inflammatory pathways has been shown to contribute to the development of chronic inflammatory diseases. n this review, we first provide an overview of miRNA biogenesis, main mechanisms of action, and currently available miRNA profiling tools. Next, we summarize the available evidence supporting a specific role for miRNAs in the pathobiology of periodontitis. Based on a review of available data on the differential expression of miRNAs in gingival tissues in states of periodontal health and disease, we address specific roles for miRNAs in molecular and cellular pathways causally linked to periodontitis. Our review points to several lines of evidence suggesting the involvement of miRNAs in periodontal tissue homeostasis and pathology. Although the intricate regulatory networks affected by miRNA function are still incompletely mapped, further utilization of systems biology tools is expected to enhance our understanding of the pathobiology of periodontitis.

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Section: Mirnas In Periodontitis and Periodontitis‐related Mechanismssupporting

confidence: 64%

Mini but mighty: microRNAs in the pathobiology of periodontal disease

Kebschull¹,

Papapanou²

2015

Periodontology 2000

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“…Of critical importance, epigenetic-mediated regulations play a central role in the cell's response pathways that are crucial for adaptation to hypoxia (593,717,1039). Epigeneticrelated mechanisms of DNA methylation, histone modifications, and microRNAs have all been shown to be important in maternal, placental, and fetal responses to hypoxia in gestation (156,183,212,305,616,691,754,1129). Recent studies in several animal models including gestational hypoxia have shown significant changes in gene ex-Table 3.…”

Section: Hypoxia and Epigenetic Programmingmentioning

confidence: 99%

Gestational Hypoxia and Developmental Plasticity

Ducsay

Goyal

Pearce

et al. 2018

Physiological Reviews

145

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Hypoxia is one of the most common and severe challenges to the maintenance of homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is multidimensional involving complicated intracellular networks concerned with the transduction of hypoxia-induced responses. Of all the stresses to which the fetus and newborn infant are subjected, perhaps the most important and clinically relevant is that of hypoxia. Hypoxia during gestation impacts both the mother and fetal development through interactions with an individual's genetic traits acquired over multiple generations by natural selection and changes in gene expression patterns by altering the epigenetic code. Changes in the epigenome determine "genomic plasticity," i.e., the ability of genes to be differentially expressed according to environmental cues. The genomic plasticity defined by epigenomic mechanisms including DNA methylation, histone modifications, and noncoding RNAs during development is the mechanistic substrate for phenotypic programming that determines physiological response and risk for healthy or deleterious outcomes. This review explores the impact of gestational hypoxia on maternal health and fetal development, and epigenetic mechanisms of developmental plasticity with emphasis on the uteroplacental circulation, heart development, cerebral circulation, pulmonary development, and the hypothalamic-pituitary-adrenal axis and adipose tissue. The complex molecular and epigenetic interactions that may impact an individual's physiology and developmental programming of health and disease later in life are discussed.

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“…A prototypical example is miR-210, which is HIF inducible and was initially identified in cancer cells (92). More recently, miR-210 was shown to function as a negative regulator of HIF-1␣ in T cells (161), illustrating that hypoxia-and also non-hypoxia-regulated miRs operate in complex feedback loops that can amplify or suppress HIF-controlled pathways (31) and thus have the potential to modulate IPC. For example, miR-199a is suppressed under hypoxic conditions and modulates HIF-1-induced preconditioning in cardiomyocytes by directly targeting HIF-1␣ and SIRT1-induced suppression of PHD2 (131).…”

Section: F827mentioning

confidence: 99%

Molecular mechanisms of ischemic preconditioning in the kidney

Kapitsinou

Haase

2015

American Journal of Physiology-Renal Physiology

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More effective therapeutic strategies for the prevention and treatment of acute kidney injury (AKI) are needed to improve the high morbidity and mortality associated with this frequently encountered clinical condition. Ischemic and/or hypoxic preconditioning attenuates susceptibility to ischemic injury, which results from both oxygen and nutrient deprivation and accounts for most cases of AKI. While multiple signaling pathways have been implicated in renoprotection, this review will focus on oxygen-regulated cellular and molecular responses that enhance the kidney's tolerance to ischemia and promote renal repair. Central mediators of cellular adaptation to hypoxia are hypoxia-inducible factors (HIFs). HIFs play a crucial role in ischemic/hypoxic preconditioning through the reprogramming of cellular energy metabolism, and by coordinating adenosine and nitric oxide signaling with antiapoptotic, oxidative stress, and immune responses. The therapeutic potential of HIF activation for the treatment and prevention of ischemic injuries will be critically examined in this review.

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Robustness of the hypoxic response: Another job for miRNAs?

Cited by 9 publications

References 86 publications

Mini but mighty: microRNAs in the pathobiology of periodontal disease

Mini but mighty: microRNAs in the pathobiology of periodontal disease

Gestational Hypoxia and Developmental Plasticity

Molecular mechanisms of ischemic preconditioning in the kidney

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