Robustness of tuned mixing within a droplet for digital microfluidics

Chabreyrie, Rodolphe; Vainchtein, Dmitri; Chandre, Cristel; Singh, Pushpendra; Aubry, Nadine

doi:10.1016/j.mechrescom.2008.06.010

Cited by 10 publications

(4 citation statements)

References 29 publications

(35 reference statements)

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“…The flow pattern and the mixing in droplets was also considered in numerical simulations of straight channels [362,363,368,369] and of serpentine channels [370]. It was shown that the friction between the droplet and the channel wall increased with decreasing thickness of the fluid layer of the continuous phase between droplet and channel wall.…”

Section: Mixing In Droplets and Flow Profilesmentioning

confidence: 99%

Droplet based microfluidics

et al. 2011

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Droplet based microfluidics is a rapidly growing interdisciplinary field of research combining soft matter physics, biochemistry and microsystems engineering. Its applications range from fast analytical systems or the synthesis of advanced materials to protein crystallization and biological assays for living cells. Precise control of droplet volumes and reliable manipulation of individual droplets such as coalescence, mixing of their contents, and sorting in combination with fast analysis tools allow us to perform chemical reactions inside the droplets under defined conditions. In this paper, we will review available drop generation and manipulation techniques. The main focus of this review is not to be comprehensive and explain all techniques in great detail but to identify and shed light on similarities and underlying physical principles. Since geometry and wetting properties of the microfluidic channels are crucial factors for droplet generation, we also briefly describe typical device fabrication methods in droplet based microfluidics. Examples of applications and reaction schemes which rely on the discussed manipulation techniques are also presented, such as the fabrication of special materials and biophysical experiments.

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Section: Mixing In Droplets and Flow Profilesmentioning

confidence: 99%

Droplet based microfluidics

et al. 2011

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“…Although such a device would not produce exactly the one harmonic angular velocity profile described in Eq. ( 5), our previous study [37] has shown that the strategy is robust with respect to the specific time dependent function used for the rotation. Specifically, results were very similar when the sinusoidal rotation was replaced by a periodic triangular function.…”

Section: Design Of An Experimental Set Upmentioning

confidence: 95%

Using resonances to control chaotic mixing within a translating and rotating droplet

Chabreyrie¹,

Vainchtein²,

Chandre³

et al. 2010

Communications in Nonlinear Science and Numerical Simulation

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Enhancing and controlling chaotic advection or chaotic mixing within liquid droplets is crucial for a variety of applications including digital microfluidic devices which use microscopic "discrete" fluid volumes (droplets) as microreactors. In this work, we consider the Stokes flow of a translating spherical liquid droplet which we perturb by imposing a time-periodic rigid-body rotation. Using the tools of dynamical systems, we have shown in previous work that the rotation not only leads to one or more three-dimensional chaotic mixing regions, in which mixing occurs through the stretching and folding of material lines, but also offers the possibility of controlling both the size and the location of chaotic mixing within the drop. Such a control was achieved through appropriate tuning of the amplitude and frequency of the rotation in order to use resonances between the natural frequencies of the system and those of the external forcing. In this paper, we study the influence of the orientation of the rotation axis on the chaotic mixing zones as a third parameter, as well as propose an experimental set up to implement the techniques discussed.

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“…1,2 Furthermore, particles on drops' surfaces can be advantageous in the field of digital microfluidics, which uses droplets, rather than fluid streams, to transport, concentrate and mix fluid and particles, for developing programmable micro-chips with bio-chemical reactions occurring within single droplets. [5][6][7][8] Particularly, particles can be transported at drops' surfaces rather than within drops, and as we see below, can be delivered relatively easily from that location compared to the core of the drop.…”

Section: Introductionmentioning

confidence: 96%