2004
DOI: 10.1373/clinchem.2004.037960
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ROC Analysis Comparison of Three Assays for the Detection of Antibodies against Double-Stranded DNA in Serum for the Diagnosis of Systemic Lupus Erythematosus

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Cited by 10 publications
(5 citation statements)
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“…Even if more differences emerge among the EIA methods, results of the present study suggest that commercial EIA methods available today seem to have overcome several problems of first-generation assays using immobilized dsDNA. Similarly to the report from Wasmuth et al, 16 our study shows how EIA methods today present a diagnostic efficiency comparable to or, in some cases, superior to the Farr method used in our study. The CLIFT method confirmed its higher specificity but also its lower sensitivity, in that 28% of patients with SLE who tested dsDNA-positive with the EIA method also tested negative with the CLIFT method.…”
Section: Discussionsupporting
confidence: 91%
“…Even if more differences emerge among the EIA methods, results of the present study suggest that commercial EIA methods available today seem to have overcome several problems of first-generation assays using immobilized dsDNA. Similarly to the report from Wasmuth et al, 16 our study shows how EIA methods today present a diagnostic efficiency comparable to or, in some cases, superior to the Farr method used in our study. The CLIFT method confirmed its higher specificity but also its lower sensitivity, in that 28% of patients with SLE who tested dsDNA-positive with the EIA method also tested negative with the CLIFT method.…”
Section: Discussionsupporting
confidence: 91%
“…At a cut-off value of 1.0 RU, the sensitivity and specificity were found to be 46.9 and 92.8%, respectively. These values approach those of the sensitivity and specificity of anti-dsDNA aab assays [29].…”
Section: Difference In the Individual Centersmentioning
confidence: 57%
“…Differences with P value\0.05 were considered significant. Receiver operating characteristic (ROC) analysis was carried out to analyze the discrimination between patients with SLE and various controls [29].…”
Section: Statistical Evaluationmentioning
confidence: 99%
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“…The specificity and sensitivity for SLE of anti-DNA antibodies depends on the assay used for its detection and the patient population studied and varies widely (Table 22.1; compiled from [7,[12][13][14][15]). In one meta-analysis, ELISA, CLIFT, and Farr assay were compared [16].…”
Section: Specificity and Sensitivitymentioning
confidence: 99%