Rocky Mountain Spotted Fever in Dogs Associated with Human Patients in Ohio

Gordon, John C.; Gordon, Scoft W.; Peterson, Ellen; Philip, Robert N.

doi:10.1093/infdis/148.6.1123

Cited by 6 publications

(2 citation statements)

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“…Dogs themselves are susceptible to infection and clinical cases, sometimes fatal, have been described [7] – [14] . Because of their susceptibility to R. rickettsii and relatively high rates of tick exposure, dogs may serve as sentinels of risk for RMSF in people [3] , [15] – [17] . The drug of choice for treating RMSF in dogs, as in humans, is doxycycline with the recommended treatment regimens of either 5–10 mg/kg/day for 10–21 days [18] , or 10–20 mg/kg twice/day for 1 week [19] regardless of the age of the dog.…”

Section: Introductionmentioning

confidence: 99%

Clinical Presentation, Convalescence, and Relapse of Rocky Mountain Spotted Fever in Dogs Experimentally Infected via Tick Bite

et al. 2014

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Rocky Mountain spotted fever (RMSF) is a tick-borne disease caused by R. rickettsii in North and South America. Domestic dogs are susceptible to infection and canine RMSF can be fatal without appropriate treatment. Although clinical signs of R. rickettsii infection in dogs have been described, published reports usually include descriptions of either advanced clinical cases or experimental infections caused by needle-inoculation of cultured pathogen rather than by tick bite. The natural progression of a tick-borne R. rickettsii infection has not been studied in sufficient detail. Here, we provide a detailed description of clinical, hematological, molecular, and serological dynamics of RMSF in domestic dogs from the day of experimental exposure to infected ticks through recovery. Presented data indicate that neither the height/duration of fever nor detection of rickettsial DNA in dogs' blood by PCR are good indicators for clinical prognosis. Only the apex and subsequent subsidence of neutrophilia seem to mark the beginning of recovery and allow predicting a favorable outcome in Rickettsia-infected dogs, even despite the continuing persistence of mucosal petechiae and skin rash. On the other hand the appropriate (doxycycline) antibiotic therapy of sufficient duration is crucial in prevention of RMSF relapses in dogs.

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Section: Introductionmentioning

confidence: 99%

Clinical Presentation, Convalescence, and Relapse of Rocky Mountain Spotted Fever in Dogs Experimentally Infected via Tick Bite

et al. 2014

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“…Disease manifestations are strikingly similar in people and in dogs 1,2,5,7–9 . Illness in dogs can precede illness in people in the same household 4,10‐13 . Rickettsia rickettsii ( R. rickettsii) has been identified as a select agent by the Centers for Disease Control and Prevention, and as a category C priority pathogen by the National Institute of Allergic and Infectious Disease (NIAID) because of concerns that it is amenable to use as a biological weapon 14 .…”

Section: Background and Purposementioning

confidence: 99%

Molecular Characterization of Rickettsia rickettsii Infecting Dogs and People in North Carolina

Kidd

Hegarty

Sexton

et al. 2006

Annals of the New York Academy of Sciences

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Rocky Mountain spotted fever (RMST) is an important cause of morbidity and mortality in people and dogs in the United States. Disease manifestations are strikingly similar in both species, and illness in dogs can precede illness in people. R. rickettsii has been identified as a Select Agent by the CDC as a Category C priority pathogen by the National Institute of Allergic and Infectious Diseases because it is amenable to use as a bioterror agent. The clinical and temporal relationship of naturally occurring diseases in dogs and people suggests that dogs could serve as sentinels for natural infection and bioterrorist attacks using this organism. Recognizing genetic modifications in naturally occurring disease agents in order to distinguish them from intentionally released agents are priorities put forth by the NIAID. To determine whether the rickettsiae naturally infecting dogs is the same as those that infect persons in a given geographical region, we characterized rickettsial isolates obtained from three dogs and two persons diagnosed with RMSF in North Carolina. Portions of three genes (ompA, rrs, and gltA) amplified by PCR were cloned and sequenced or directly sequenced. Reactions were run in duplicate in forward and reverse directions. Gene sequences were aligned with known sequences deposited in GenBank and with each other. Sequences of the 5' region of the ompA gene were 100% homologous with a tick strain (Bitterroot) of R. rickettsii for all five isolates. Sequences of the rrs gene were 99.8 99.9% homologous with a tick strain (Sawtooth) of R. rickettsii. rrs gene sequences from one dog and the two persons was identical. Sequences of one dog isolate differed from these by one base pair. Sequences from another dog isolate differed by two base pairs. Sequences of the gltA gene are pending. This confirms on a molecular level that R. rickettsii causing naturally occurring RMSF in dogs in North Carolina is highly homologous to R. rickettsii that causes the disease in people in the same region. Sequence data will be deposited in GenBank, thereby providing genetic information regarding naturally occurring R. rickettsii.

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Future challenges for parasitology: Vector control and one health in the Americas

Little

2013

Veterinary Parasitology

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Rocky Mountain Spotted Fever in Dogs Associated with Human Patients in Ohio

Cited by 6 publications

References 0 publications

Clinical Presentation, Convalescence, and Relapse of Rocky Mountain Spotted Fever in Dogs Experimentally Infected via Tick Bite

Clinical Presentation, Convalescence, and Relapse of Rocky Mountain Spotted Fever in Dogs Experimentally Infected via Tick Bite

Molecular Characterization of Rickettsia rickettsii Infecting Dogs and People in North Carolina

Future challenges for parasitology: Vector control and one health in the Americas

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