Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy

Yang, Lifang; Ren, Chuchu; Xu, Min; Song, Yilin; Lu, Qi; Wang, Yule; Zhu, Yan; Wang, Xinxing; Li, Nan

doi:10.1007/s12274-020-2844-3

Cited by 50 publications

(29 citation statements)

References 43 publications

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“…Yang et al 89 . integrate MnO 2 and ultrasmall AuNPs by depositing them on mesoporous silica nanorods and developed biomimetic hybrid inorganic MnO 2 –Au nanozymes (MSNR@MnO 2 –Au).…”

Section: Integration Of Nanozyme For Cancer Therapymentioning

confidence: 99%

Nanomaterials for cascade promoted catalytic cancer therapy

Tong

Gao

Huang

et al. 2021

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Catalytic therapy utilizing special substances (e.g., hydrogen peroxide and glucose) in tumor sites has attracted wide interest to achieve tumor‐specific therapy or improve the efficacy of other treatments. Benefiting from the selectivity and high activity of catalytic chemistry, efficient cancer therapy is available with negligible side effects. Numerous works, which are focused on further augmenting catalytic therapy with cascade strategies, have been reported with biocompatible nanomaterials composed of natural enzymes and/or nanozymes. Herein, we summarized catalytic reactions and nanomaterials in cascade strategy‐involved cancer therapy. With rapid advances in chemistry and nanomaterials, developing more selective and efficient cascade catalytic strategies will continue to be promising and challenging for cancer therapy.

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“…Yang et al 89 . integrate MnO 2 and ultrasmall AuNPs by depositing them on mesoporous silica nanorods and developed biomimetic hybrid inorganic MnO 2 –Au nanozymes (MSNR@MnO 2 –Au).…”

Section: Integration Of Nanozyme For Cancer Therapymentioning

confidence: 99%

Nanomaterials for cascade promoted catalytic cancer therapy

Tong

Gao

Huang

et al. 2021

VIEW

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“…Therefore, how to comprehensively suppress the immunosuppressive tumor microenvironment (TME) is still a major challenge for immunotherapy to maximize the benefit. Phototherapy has been shown to induce immunogenic cell death (ICD), recruitment antigen-presenting cells to phagocytize tumor cell antigens and further activate T cell adaptive immune response (Li et al, 2019 ; Yang et al, 2020a , b , c ; Alzeibak et al, 2021 ). Therefore, the particles coated with erythrocyte membrane can not only improve the effect of phototherapy but also improve the immune effect.…”

Section: Cell Membrane Biomimetic Platform For Phototherapymentioning

confidence: 99%

“…Yang et al ( 2020a , b , c ) proposed a strategy that can not only increase tumor infiltration for lymphocyte recruitment but also comprehensively reprogram the immunosuppressive TME for enhanced phototherapy and immunotherapy ( Figure 3 ). They synthesized a thermal-sensitive SNO donor-pendant copolymer (poly(acrylamide-co-acrylonitrile-co-vinylimidazole)-SNO, PAAV-SNO) and self-assembled it with NIR II photothermal agent IR1061 and indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor 1-methyl-tryptophan (1-MT).…”

Section: Cell Membrane Biomimetic Platform For Phototherapymentioning

confidence: 99%

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Biomimetic phototherapy in cancer treatment: from synthesis to application

2021

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Phototherapy, with minimally invasive and cosmetic effect, has received considerable attention and been widely studied in cancer treatment, especially in biomaterials field. However, most nanomaterials applied for the delivery of phototherapy agents are usually recognized by the immune system or cleared by liver and kidney, thus hindering their clinical applications. To overcome these limitations, bionic technology stands out by virtue of its low antigenicity and targeting properties, including membrane bionics and bionic enzymes. In this review, we will summarize the up-to-date progress in the development of biomimetic camouflage-based nanomaterials for phototherapy, from synthesis to application, and their future in cancer treatment.

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“…[ 9 ] The enzyme‐catalysis of intracellular glucose has been adopted to make H 2 O 2 generation, including glucose oxidase (GOD) and other nanozyme, [ 10 ] such as Au nanoparticles. [ 11 ] Alternatively, some peroxides, including CuO 2 , CaO 2 and MgO 2 have also been used to boost the endogenous H 2 O 2 level. [ 12 ] Nevertheless, the direct delivery suffers from the safe risk, and the enzyme‐catalysis depends on both O 2 and glucose.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of MoSe₂/CoSe₂ Nanosheets for NIR‐Enhanced Chemodynamic Therapy via Synergistic In‐Situ H₂O₂ Production and Activation

Yang

Jia

Lin

et al. 2020

Adv Funct Materials

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Currently, the limited intratumoral H2O2 level restricts the development of chemodynamic therapy (CDT). Herein, MoSe2/CoSe2@PEG nanosheets are prepared to reveal NIR‐photocatalytic H2O2 generation to insure the intracellular H2O2 supplement. The formation mechanism is investigated, showing the dissolved O2 and photo‐excited electrons to determine H2O2 production via sequential single‐electron transfer process. The experimental data and density functional theory calculation further display their typical‐II heterostructure, which possesses the effective charge separation and nearly four times H2O2 generation than MoSe2@PEG. In addition, the nanocomposites also reveal the peroxidase/catalase activity, making the in‐situ H2O2 activation and ·OH generation. And, the O2 production derived from catalase‐mimic activity not only relieves hypoxia but also offers the source for H2O2 production. Because of the decreased resistance for charge transfer, MoSe2/CoSe2@PEGs also reveal more than three times enzyme‐activity for MoSe2@PEG. With the narrow band gap and high NIR‐harvest, MoSe2/CoSe2@PEG exhibits the great photothermal converting ability (62.5%). MoSe2/CoSe2@PEG reveals the novel biodegradation, and most of them can be eliminated via urine and feces within 2 weeks. Here, the computed tomography/magnetic resonance imaging/photothermal imaging and the synergistic photothermal therapy/CDT treatments further make sure potential application on anticancer.

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Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy

Cited by 50 publications

References 43 publications

Nanomaterials for cascade promoted catalytic cancer therapy

Nanomaterials for cascade promoted catalytic cancer therapy

Biomimetic phototherapy in cancer treatment: from synthesis to application

Synthesis of MoSe₂/CoSe₂ Nanosheets for NIR‐Enhanced Chemodynamic Therapy via Synergistic In‐Situ H₂O₂ Production and Activation

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Rod-shape inorganic biomimetic mutual-reinforcing MnO2-Au nanozymes for catalysis-enhanced hypoxic tumor therapy

Cited by 50 publications

References 43 publications

Nanomaterials for cascade promoted catalytic cancer therapy

Nanomaterials for cascade promoted catalytic cancer therapy

Biomimetic phototherapy in cancer treatment: from synthesis to application

Synthesis of MoSe2/CoSe2 Nanosheets for NIR‐Enhanced Chemodynamic Therapy via Synergistic In‐Situ H2O2 Production and Activation

Contact Info

Product

Resources

About

Synthesis of MoSe₂/CoSe₂ Nanosheets for NIR‐Enhanced Chemodynamic Therapy via Synergistic In‐Situ H₂O₂ Production and Activation