Rod signaling in primate retina: range, routing and kinetics

Wn, Grimes; Baudin, Jacob; Azevedo, Anthony W.

doi:10.1101/352419

Cited by 2 publications

(2 citation statements)

References 57 publications

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“…Horizontal cells were adapted for at least 2 min to a background of 350 R*/M-cone/s before data collection (equivalent to ;1100 R*/rod/s or ;175 R*/L-cone/s). Rod signals are saturated at this background (Grimes et al, 2018).…”

Section: Methodsmentioning

confidence: 95%

Predicting and Manipulating Cone Responses to Naturalistic Inputs

2021

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Primates explore their visual environment by making frequent saccades, discrete and ballistic eye movements that direct the fovea to specific regions of interest. Saccades produce large and rapid changes in input. The magnitude of these changes and the limited signaling range of visual neurons mean that effective encoding requires rapid adaptation. Here, we explore how macaque cone photoreceptors maintain sensitivity under these conditions. Adaptation makes cone responses to naturalistic stimuli highly nonlinear and dependent on stimulus history. Such responses cannot be explained by linear or linear-nonlinear models but are well explained by a biophysical model of phototransduction based on well-established biochemical interactions. The resulting model can predict cone responses to a broad range of stimuli and enables the design of stimuli that elicit specific (e.g., linear) cone photocurrents. These advances will provide a foundation for investigating the contributions of cone phototransduction and post-transduction processing to visual function.

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Section: Methodsmentioning

confidence: 95%

Predicting and Manipulating Cone Responses to Naturalistic Inputs

2021

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“…This was limited to 2–3 locations per fovea given its small size. The minimum light level used (500 R*/cone/s) was sufficient to effectively eliminate rod responses (Grimes et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

S-cone photoreceptors in the primate retina are functionally distinct from L and M cones

Baudin

Angueyra

Sinha

2019

eLife

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Daylight vision starts with signals in three classes of cone photoreceptors sensitive to short (S), middle (M), and long (L) wavelengths. Psychophysical studies show that perceptual sensitivity to rapidly varying inputs differs for signals originating in S cones versus L and M cones; notably, S-cone signals appear perceptually delayed relative to L- and M-cone signals. These differences could originate in the cones themselves or in the post-cone circuitry. To determine if the cones could contribute to these and related perceptual phenomena, we compared the light responses of primate S, M, and L cones. We found that S cones generate slower light responses than L and M cones, show much smaller changes in response kinetics as background-light levels increase, and are noisier than L and M cones. It will be important to incorporate these differences into descriptions of how cone signaling shapes human visual perception.

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Rod signaling in primate retina: range, routing and kinetics

Abstract: 29Stimulus or context dependent routing of neural signals through parallel pathways can

Cited by 2 publications

References 57 publications

Predicting and Manipulating Cone Responses to Naturalistic Inputs

Predicting and Manipulating Cone Responses to Naturalistic Inputs

S-cone photoreceptors in the primate retina are functionally distinct from L and M cones

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