Rodent-Borne Orthohantaviruses in Vietnam, Madagascar and Japan

Kikuchi, Fumio; Senoo, Kae; Arai, Satoru; Tsuchiya, Koichiro; Sơn, Nguyễn Trường; Motokawa, Masaharu; Ranorosoa, Marie Claudine; Bawm, Saw; Lin, Kyaw San; Suzuki, Hitoshi; Unno, Akira; Nakata, Keisuke; Harada, Masashi; Tanaka‐Taya, Keiko; Morikawa, Shigeru; Suzuki, Motoi; Mizutani, Tetsuya; Yanagihara, Richard

doi:10.3390/v13071343

Cited by 5 publications

(5 citation statements)

References 51 publications

(64 reference statements)

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“…All amplicons matching the expected size were sequenced, resulting in partial L segments of 347bp. Genetic identity with previously reported hantaviruses from Madagascar (Kikuchi et al, 2021;Raharinosy et al, 2018a;Reynes et al, 2014b) ranged between 85.0% and 91.6%.…”

Section: Genetic Diversity Of the Newly Found Hantavirussupporting

confidence: 71%

“…Non-native Muridae rodents ( Rattus and Mus ) and Soricidae shrews ( Suncus ) also inhabit the island. This isolation and diversity may explain the evolution of unique hantavirus lineages described from the island such as Anjozorobe virus (ANJZV), a variant of Thailand virus ( Orthohantavirus thailandense ), which was found in introduced Rattus rattus and endemic Eliurus majori on Madagascar (Filippone et al, 2016; Kikuchi et al, 2021; Raharinosy et al, 2018a; Reynes et al, 2014). Human exposure to ANJZV in Madagascar is estimated at 2.7% nationally, with higher seroprevalence (7.2%) in communities adjacent to forests (Rabemananjara et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Effect of habitat degradation on hantavirus infection among introduced and endemic small mammals of Madagascar

Dubrulle,

Kauffman,

Soarimalala

et al. 2023

Preprint

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Hantaviruses are globally distributed zoonotic pathogens capable of causing fatal disease in humans. Rodents and other small mammals are the typical reservoirs of hantaviruses, though the particular host varies regionally. Addressing the risk of hantavirus spillover from animal reservoirs to humans requires identifying the local mammal reservoirs and the predictors of infection in those animals, such as their population density and habitat characteristics. We screened native and non-native small mammals and bats in northeastern Madagascar for hantavirus infection to investigate the influence of habitat, including effects of human land use on viral prevalence. We trapped 227 bats and 1663 small mammals over 5 successive years in and around Marojejy National Park across a range of habitat types including villages, agricultural fields, regrowth areas, and secondary and semi-intact forests. Animals sampled included endemic tenrecs (Tenrecidae), rodents (Nesomyidae) and bats (6 families), along with non-native rodents (Muridae) and shrews (Soricidae). A hantavirus closely related to the previously described Anjozorobe virus infected 9.5% ofRattus rattussampled. We did not detect hantaviruses in any other species. Habitat degradation had a complex impact on hantavirus prevalence in our study system: more intensive land use increase the abundance ofR. rattus. The average body size of individuals varied between agricultural and non-agricultural land-use types, which in turn affected infection prevalence. SmallerR.rattushad lower probability of infection and were captured more commonly in villages and forests. Thus, infection prevalence was highest in agricultural areas. These findings provide new insights to the gradients of hantavirus exposure risk for humans in areas undergoing rapid land use transformations associated with agricultural practices.

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Section: Genetic Diversity Of the Newly Found Hantavirussupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Effect of habitat degradation on hantavirus infection among introduced and endemic small mammals of Madagascar

Dubrulle,

Kauffman,

Soarimalala

et al. 2023

Preprint

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“…As exceptions to the one-mammal-one-hantavirus rule became more frequent than the rule itself [ 94 , 95 ], it became apparent that hantavirid co-speciation with hosts is just one factor that influenced hantavirid evolution. Genomic segment reassortment among hantavirids [ 96 ], host spillover, and host-switching [ 97 , 98 , 99 , 100 , 101 , 102 ] have likely occurred many times and obfuscated the evolutionary history of the family Hantaviridae .…”

Section: Evolution Of Hantaviridsmentioning

confidence: 99%

A Brief History of Bunyaviral Family Hantaviridae

Kuhn

Schmaljohn

2023

Diseases

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The discovery of Hantaan virus as an etiologic agent of hemorrhagic fever with renal syndrome in South Korea in 1978 led to identification of related pathogenic and nonpathogenic rodent-borne viruses in Asia and Europe. Their global distribution was recognized in 1993 after connecting newly discovered relatives of these viruses to hantavirus pulmonary syndrome in the Americas. The 1971 description of the shrew-infecting Hantaan-virus-like Thottapalayam virus was long considered an anomaly. Today, this virus and many others that infect eulipotyphlans, bats, fish, rodents, and reptiles are classified among several genera in the continuously expanding family Hantaviridae.

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“…HTNV was first discovered in South Korea in 1978 [ 10 ]. HTNV is mainly distributed in China, South Korea, Russia, and Vietnam [ 5 , 11 ]. More than 90% of global HFRS cases are reported from mainland China, with most of them being caused by HTNV [ 12 ].…”

Section: Diseases Caused By Hantavirusesmentioning

confidence: 99%

Zoonotic Hantaviridae with Global Public Health Significance

Chen

Gong

Xiu

et al. 2023

Viruses

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Hantaviridae currently encompasses seven genera and 53 species. Multiple hantaviruses such as Hantaan virus, Seoul virus, Dobrava-Belgrade virus, Puumala virus, Andes virus, and Sin Nombre virus are highly pathogenic to humans. They cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome or hantavirus pulmonary syndrome (HCPS/HPS) in many countries. Some hantaviruses infect wild or domestic animals without causing severe symptoms. Rodents, shrews, and bats are reservoirs of various mammalian hantaviruses. Recent years have witnessed significant advancements in the study of hantaviruses including genomics, taxonomy, evolution, replication, transmission, pathogenicity, control, and patient treatment. Additionally, new hantaviruses infecting bats, rodents, shrews, amphibians, and fish have been identified. This review compiles these advancements to aid researchers and the public in better recognizing this zoonotic virus family with global public health significance.

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Rodent-Borne Orthohantaviruses in Vietnam, Madagascar and Japan

Cited by 5 publications

References 51 publications

Effect of habitat degradation on hantavirus infection among introduced and endemic small mammals of Madagascar

Effect of habitat degradation on hantavirus infection among introduced and endemic small mammals of Madagascar

A Brief History of Bunyaviral Family Hantaviridae

Zoonotic Hantaviridae with Global Public Health Significance

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