Rodent Model of Irritable Bowel Syndrome

Wang, Yinshu; Bi, Zijuan; Wang, Enkang; Sun, Binbin; Zheng, Yujiao; Zhong, Linda Ld; Yuan, Judy Chia Chun

doi:10.15344/2393-8498/2017/131

Cited by 11 publications

(17 citation statements)

References 54 publications

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“…In a recent review on IBS animal models, Wang et al [105] noted that the underlying pathogenic mechanisms of IBS remain ambiguous, although increased epithelial permeability, inflammation, visceral hypersensitivity, and altered brain-gut interaction are thought to play an essential role. However, the most used method to obtain IBS symptomatology in animal models is stress exposure despite the action sites of stimuli.…”

Section: Oxidative Way Of Thinkingmentioning

confidence: 99%

Irritable Bowel Syndrome between Molecular Approach and Clinical Expertise—Searching for Gap Fillers in the Oxidative Stress Way of Thinking

et al. 2020

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Irritable bowel syndrome (IBS) remains to date an intriguing functional gastrointestinal disorder. Recent studies described a multitude of exogenous factors that work together in IBS, gradually impairing intestinal lining cellular metabolism, including oxidative status balance, with or without a genetic background. Although the current biomarkers support the differentiation between IBS subtypes and other functional gastrointestinal disorder, they are mostly non-specific, referring to clinical, biochemical, and inflammatory imbalances. Since IBS could be also the result of deficient signaling pathways involving both gastrointestinal secretion and neuro-vegetative stimulation, IBS makes no exception from the oxidative hypothesis in the pathological mechanisms. Regarding the oxidative stress implication in IBS, the previous research efforts showed controversial results, with some animal models and patient studies reporting clear oxidative imbalance both on systemic and local levels, but still with no concrete evidence to point to a direct correlation between oxidative stress and IBS. Additionally, it seems that a major role could be also attributed to gut microbiota and their ability to shape our bodies and behaviors. Moreover, the genetic features study in IBS patients showed that several genetic similarities point to a possible correlation of IBS with affective spectrum disorders. Thus, we focus here the discussion on the assumption that IBS could in fact be more likely a stress-related disorder rather than a gastrointestinal one.

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Section: Oxidative Way Of Thinkingmentioning

confidence: 99%

Irritable Bowel Syndrome between Molecular Approach and Clinical Expertise—Searching for Gap Fillers in the Oxidative Stress Way of Thinking

et al. 2020

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“…Animal shows abnormal defection after restrain stress. This model reproduced, at least in part, the main symptoms present in IBS, visceral hypersensitivity and dysmotility [16,17]. The efficacy of this test is confirmed by the development of an immediate hyperalgesia [18], the inhibition of small intestinal transit, the stimulation of large intestinal activity and the incidence of an increased fecal excretion [15].…”

Section: Discussionmentioning

confidence: 56%

The effects of three novel probiotics isolated from the Korean fermented food Kimchi on the stress-induced defecation of rats

Kim

Lee

et al. 2020

Precis Future Med

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Purpose: The interest in novel probiotics that improve symptoms of irritable bowel syndrome (IBS) has been growing trend. This study aims to investigate the probiotic effect of three kinds of Lactobacillus strain that are isolated from kimchi. Methods: We used Wister strain rats, male sex. The rat subjects were subdivided into four groups by which to be administered Lactobacillus casei DK128, Lactobacillus paracasei DK121, Lactobacillus platarum DK119 or vesicle only (control). Each Lactobacillus (1 × 10 9 colony forming unit) was administered by oral gavage once daily for 10 days. At day 10, the rats were stressed by being placed in confinement in a restraining stress cage for 1 hour. The stool of the animals were collected after the stress test. The stool weight was recorded and measured in grams, then, each data were transformed to a percentage as compared with the mean stool weight of same age in control group. The stool consistency was scored 0 to 4 (0, normal; 2, loose stool; 4, diarrhea). We compared the stool weight and consistency between the treatments. Results: The total stool weight of the rats was significantly reduced in the L. casei DK128 group (65%, P = 0.0368) and the L. paracasei DK121 group (64%, P = 0.0138), as compared to the control group (100%). The stool consistency of the L. paracasei DK121 group was noted as being better than the control group (2 vs. 4, P = 0.0272). Conclusion: Our findings suggest that L. casei DK128 and L. paracasei DK121 has the characteristics of probiotics that could control symptoms of IBS.

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“…However, it was concluded that IBS animal model results were not sufficient to identify the exact cause of the disease or effective treatment approaches in humans. 26 The available human studies that investigated OS in patients with IBS reported inconsistent results. Preidis et al reported increased systemic protein and lipid peroxidation in IBS patients via a similar antioxidant pathway compared to healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

“…'s review, it was noted that increased epithelial permeability, inflammation, visceral hypersensitivity, and altered brain‐gut interactions are strong candidates for the etiopathogenesis of IBD. However, it was concluded that IBS animal model results were not sufficient to identify the exact cause of the disease or effective treatment approaches in humans 26 . The available human studies that investigated OS in patients with IBS reported inconsistent results.…”

Section: Discussionmentioning

confidence: 99%

Altered thiol/disulfide homeostasis and ischemia‐modified albumin levels in children with irritable bowel syndrome

Durankuş¹,

Şenkal²,

Cam³

et al. 2021

Pediatrics International

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Background: In this study, we assessed thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with irritable bowel syndrome (IBS) compared with healthy children. Methods: Fifty-six children with IBS and 53 healthy children were included in the study after assessment of inclusion and exclusion criteria. Plasma thiol/disulfide and IMA levels were compared between children with and without IBS.

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Rodent Model of Irritable Bowel Syndrome

Cited by 11 publications

References 54 publications

Irritable Bowel Syndrome between Molecular Approach and Clinical Expertise—Searching for Gap Fillers in the Oxidative Stress Way of Thinking

Irritable Bowel Syndrome between Molecular Approach and Clinical Expertise—Searching for Gap Fillers in the Oxidative Stress Way of Thinking

The effects of three novel probiotics isolated from the Korean fermented food Kimchi on the stress-induced defecation of rats

Altered thiol/disulfide homeostasis and ischemia‐modified albumin levels in children with irritable bowel syndrome

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