Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development

Spann, Redin A.; Lawson, William J.; Bidwell, Gene L.; Zamarripa, C. Austin; Marañón, Rodrigo O; Bandyopadhyay, Sibali; Taylor, Erin R.; Reckelhoff, Jane F.; Garrett, Michael R.; Grayson, Bernadette E.

doi:10.1042/cs20171416

Cited by 19 publications

(47 citation statements)

References 63 publications

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“…With elevations in both VSG males [ 30 ] and females, one might hypothesize VSG animals have increased blood pressure. In fact, females having undergone VSG have either no change or reduced blood pressure both prior to pregnancy and during gestation [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Anxiety behavior and hypothalamic-pituitary-adrenal axis altered in a female rat model of vertical sleeve gastrectomy

et al. 2018

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Surgical weight loss results in a host of metabolic changes that culminate in net positive health benefit to the patients. However, the psychological impact of these surgeries has not been fully studied. On one hand, surgical weight loss has been reported to improve standard quality of life and resolution of symptoms of depression. But on the other hand, reports of self-harm and increased ER visits for self-harm suggest other psychological difficulties. Inability to handle anxiety following surgical weight loss has alarming potential ramifications for these gastric surgery patients. In the present study, we used models of diet-induced obesity and vertical sleeve gastrectomy (VSG) to ask whether anxiety behavior and hypothalamic-pituitary-adrenal (HPA) axis gene changes were affected by surgical weight loss under two diet regimens: i.e. low-fat diet (LFD) and high-fat diet (HFD). We show reduced exploratory behavior in the open field test but increased time in the open arms of the elevated plus maze. Furthermore, we show increased plasma levels of corticosterone in female VSG recipients in the estrus phase and increased levels of hypothalamic arginine-vasopressin (avp), pro-opiomelanocortin (pomc), and tyrosine hydroxylase (th). We report reduced dopamine receptor D1 (drd1) gene in prefrontal cortex (PFC) in VSG animals in comparison to Sham. Further we report diet-driven changes in stress-relevant gene targets in the hypothalamus (oxt, pomc, crhr1) and adrenal (nr3c1, nr3c2, mc2r). Taken together, these data suggest a significant impact of both surgical weight loss and diet on the HPA axis and further impact on behavior. Additional assessment is necessary to determine whether molecular and hormonal changes of surgical weight loss are the source of these findings.

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Section: Discussionmentioning

confidence: 99%

Anxiety behavior and hypothalamic-pituitary-adrenal axis altered in a female rat model of vertical sleeve gastrectomy

et al. 2018

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“…33 In our present work, the most profound difference we observed in the milk was in the levels of adiponectin where H-VSG had the highest levels of adiponectin. Since circulating plasma adiponectin varies inversely with adiposity, it is not surprising that VSG has the highest amount of milk adiponectin; 7,34 however, it is interesting that C-Sham dams produce the lowest levels of adiponectin in milk despite having lower levels of adiposity compared to H-Sham in every study that we have performed. 7,34 In a study of maternal milk collected at 6 weeks postpartum, adiponectin levels were predictive for being overweight at 24 months of age; high milk adiponectin levels were thus a risk factor for overweight offspring later in life.…”

Section: Variations In Hormonal Regulators Of Appetite In Breast Milkmentioning

confidence: 95%

“…Since circulating plasma adiponectin varies inversely with adiposity, it is not surprising that VSG has the highest amount of milk adiponectin; 7,34 however, it is interesting that C-Sham dams produce the lowest levels of adiponectin in milk despite having lower levels of adiposity compared to H-Sham in every study that we have performed. 7,34 In a study of maternal milk collected at 6 weeks postpartum, adiponectin levels were predictive for being overweight at 24 months of age; high milk adiponectin levels were thus a risk factor for overweight offspring later in life. 35 This is intriguing with the current VSG model since the highest adiponectin in milk is from H-VSG dams who we have shown give rise to adult pups with greater adiposity than either the C-Sham or H-Sham.…”

Section: Variations In Hormonal Regulators Of Appetite In Breast Milkmentioning

confidence: 95%

“…This is in direct contrast to the high levels of IgG that were measured in plasma at G19 during pregnancy. 34 It is possible that the IgGs in milk are depleted during early postnatal life or alternatively that IgGs do not pass normally to the infant through the placenta after VSG pregnancy.…”

Section: Milk Immunoglobulins Provide Immune Protectionmentioning

confidence: 99%

“…Some cursory observations suggest that VSG dams do not spend as much time caring for their pups as Sham dams but this would need to be studied in a controlled paradigm to define the ways in which VSG offspring may be affected by this altered maternal behavior. 34…”

Section: Caveats and Limitations To The Current Workmentioning

confidence: 99%

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Nutrient and hormone composition of milk is altered in rodent dams post-bariatric surgery

Deer

Welch

Hernández

et al. 2019

J Dev Orig Health Dis

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Although bariatric surgery is approved for a woman of child-bearing age with an interest in subsequent pregnancy, reports of in utero growth issues during pregnancy have garnered a closer look at the impact of maternal surgical weight loss on the pre- and postpartum periods. Offspring of dams having received vertical sleeve gastrectomy (VSG) are born small-for-gestational age and have increased risk for metabolic syndrome later in life. Here, we aimed to determine whether the postnatal catch-up growth trajectory of bariatric offspring may be affected by milk composition. Milk samples were collected at postnatal day 15/16 from dams having received VSG surgery and fed a high-fat diet (HFD) (H-VSG), Sham surgery and fed chow (C-Sham), or Sham surgery and fed HFD (H-Sham). Milk obtained from H-VSG dams had elevated glucose (P < 0.05) and significantly reduced triglyceride content (P < 0.01). Milk from H-Sham dams had the lowest amount of milk protein (P < 0.05). Fatty acid composition measured by fractionation was largely not affected by surgery but rather maternal diet. No difference was observed in milk leptin levels; however, insulin, adiponectin, and growth hormone levels were significantly increased in milk from H-VSG animals. H-Sham had the lowest level of immunoglobulin (Ig)A, whereas IgG was significantly reduced in H-VSG. Taken together, the quality of milk from H-VSG dams suggests that milk composition could be a factor in reducing the rate of growth during the lactation period.

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The association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery

Hilaire,

Babcock,

White

et al. 2024

Obesity

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ObjectiveThe objective of this study was to assess maternal gestational outcomes and offspring growth trajectories following prepregnancy metabolic and bariatric surgery (MBS) compared with non‐MBS controls.MethodsSingle‐center deliveries between January 2020 and March 2023 with prepregnancy Roux‐en‐Y gastric bypass (herein referred to as “bypass”), sleeve gastrectomy (herein referred to as “sleeve”), and non‐MBS controls were included. Offspring growth trajectories were compared with the World Health Organization child growth standards. Linear mixed models assessed MBS‐bypass and MBS‐sleeve offspring weight, length, and BMI trajectories with a prepregnancy BMI 27 to 37 kg/m2 and propensity score‐matched controls.ResultsThe study included 440 participants with prepregnancy MBS (MBS‐bypass, 185; MBS‐sleeve, 225; 76% Hispanic/Latino) and 13,434 non‐MBS controls. Gestational weight gain and gestational diabetes mellitus were similar, whereas hypertensive disorders of pregnancy were more common after MBS. The post‐MBS offspring had lower birth weight but higher weight gain at 24 months (sleeve, +1.4 kg [95% CI: 1.0–1.9]; bypass, +0.5–0.7 kg [95% CI: 0.0–1.2]) compared with non‐MBS groups. Male children had higher weight gain than females. The post‐MBS‐sleeve but not the post‐MBS‐bypass offspring had higher BMI z scores.ConclusionsThe higher early‐life weight gain and sex differences in the post‐MBS‐sleeve group compared with the post‐MBS‐bypass group provide a window toward elucidating pathways to mitigate intergenerational metabolic risk transfer.image

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Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development

Cited by 19 publications

References 63 publications

Anxiety behavior and hypothalamic-pituitary-adrenal axis altered in a female rat model of vertical sleeve gastrectomy

Anxiety behavior and hypothalamic-pituitary-adrenal axis altered in a female rat model of vertical sleeve gastrectomy

Nutrient and hormone composition of milk is altered in rodent dams post-bariatric surgery

The association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery

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