Rodenticide poisoning in children: A study of clinical profile and electrocardiographic changes

Sugunan, Sheeja; Krishnan, Rekha; Kumar, Kishore; Geetha, S.

doi:10.32677/ijch.2017.v04.i02.007

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…In a few studies in India, a few instances of homicidal YP poisoning have also been reported. 9,10 In other studies, similar age group preponderance was observed. 9 Children easily mistake YP paste for toothpaste and consume it.…”

Section: Discussionsupporting

confidence: 76%

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A cross-sectional study of the clinical profile of children admitted with yellow phosphorous poisoning in a tertiary care hospital

Selvaraju K,

Vijay Anand M,

Kanimozhi P

et al. 2023

Asian J Med Sci

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Background: Yellow phosphorous (YP) is a protoplasmic poison that is mainly used as a rodenticide. Aims and Objectives: The aim of the study is to describe the clinical profile of YP poisoning in children in a tertiary care hospital. Materials and Methods: This is a cross-sectional study done in a tertiary care hospital in Tamil Nadu. A convenience sample of all the cases admitted during the year 2022 was done. Demographic and clinical data were collected and analyzed. Results: The male: female ratio was 1.16:1 (n=13). The mean age of the children was 4.0769±1.373 years. About 84.61% of the children reported to the hospital within 6 h. On admission, fever (30.76%), vomiting (30.76%), abdominal pain (30.76%), bleeding (15.38%), and altered sensorium (15.38%) were the common symptoms. All the children ingested YP accidentally. Leukocytosis was observed in about 30.76%. The mean peak serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were 516.9231±685.976 IU/L and 161.9231±215.107 IU/L, respectively. There were no alterations in the Electrocardiographic tracings, levels of serum electrolytes, blood glucose, and serum creatinine in children with YP poisoning. Significant differences were observed between children who survived and children who died in the levels of mean peak AST, mean peak ALT, INR, and in the presence of encephalopathy and bleeding manifestations. Conclusion: YP is an uncommon but lethal poison in children. Creating awareness among parents about the dangers of YP and nationwide prohibition of the sale of YP will be an important step in eliminating deaths in children who are accidental victims.

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Section: Discussionsupporting

confidence: 76%

“…9,10 In other studies, similar age group preponderance was observed. 9 Children easily mistake YP paste for toothpaste and consume it.…”

Section: Discussionsupporting

confidence: 76%

A cross-sectional study of the clinical profile of children admitted with yellow phosphorous poisoning in a tertiary care hospital

Selvaraju K,

Vijay Anand M,

Kanimozhi P

et al. 2023

Asian J Med Sci

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“…In a study on ECG changes on rodenticide poisoning by Soltaninejad et al, the ECG changes or cardiovascular symptoms appeared between 3 and 5 h after admission [9]. In a study by Sugunan et al, the mean time of onset of ECG changes is 19.7 h [10]. In our study, the average time interval between intake of poison and the appearance of ECG findings was 22 h.…”

Section: Methodssupporting

confidence: 51%

A Study on Ecg Findings in Acute Liver Cell Failure Due to Rat Killer Paste Poisoning

AL,

et al. 2024

Asian J Pharm Clin Res

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Objectives: The objective of this study was to study the various electrocardiogram (ECG) manifestations in patients who develop acute liver cell failure due to rat killer paste poisoning. Methods: Patients who developed acute liver cell failure due to rat killer paste ingestion admitted during the time period of July 2022–December 2022 in our institution were taken up for the study. Serial ECG monitoring was done in all these patients and observed for any changes. Results: Eighty-eight cases of rat killer paste poisoning that developed acute liver failure during this time period were included in the study. Out of 88 patients, 24 patients (27%) had ECG manifestations. The different ECG manifestations are ST depression with T wave inversion – 13 patients (10 expired), QT prolongation – 8 patients (3 expired), sinus bradycardia – 2 patients, and atrial fibrillation with rapid ventricular rate – 1 patient (expired). The mean time of onset of ECG findings is 22 h from intake of poison. The overall mortality rate is 23% (20 patients). About 70% of expired patients (14 patients) had abnormal ECG manifestations. Conclusion: ST depression with T wave inversion was the most common ECG manifestation due to rat killer paste poisoning in our study and it correlates with mortality. Since cardiotoxicity due to rat killer paste poisoning is also a major contributor to mortality, proper measures have to be taken to create awareness to the general public regarding the toxicity of rat killer paste.

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“…At pH 4, 7.1% of zinc phosphide hydrolyzed in 12 hours, whereas 38.8% hydrolyzed at pH 2 over the same period. 7 Yellow phosphorus (white phosphorus) is commonly available as a paste which is spread over bait. "RATOL" is the most popular brand.…”

Section: Introductionmentioning

confidence: 99%

A study on outcome of rodenticide poisoning patients admitted to a tertiary care teaching hospital in relation to the chemical content of that poison

Shivakumar

Yamunaraj

2019

Int J Adv Med

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Background: Poisoning is the major health problem in India. Rodenticides are the commonest poisoning in Asian countries like India. Rodenticides are the substance used to kill rats. Prognosis mainly depends on chemical content of poison.Methods: This retrospective record-based study was conducted between January 2017 to December 2017 at government hospital department of general medicine, MIMS, Mandya, Bangalore, Karnataka, India. Data regarding age, sex, marital status, occupation, type of poison, route of exposure, and outcome of poisoning and associated co-morbid conditions were collected from the hospital records and documented in the pre-structured proforma. Descriptive analysis was carried out by the mean and standard deviation for quantitative variables, frequency and proportion for categorical variables.Results: Out of 56 patients 33 (59%) were female 23 (41%) were male. Most common age group was 20 to 30 years, followed by 31 to 40 years group. Most common poison was yellow phosphorous (41%), followed by aluminium phosphide (29%). Most common complication was hepatitis (20%),followed by cardiogenic shock (9%).Total mortality was 3 (5%).Conclusions: Among rodenticides yellow phosphorous was most common consumed poison in present study. Aluminium phosphorus was most lethal poison. Even though there is no specific antidote, early symptomatic treatment is the key in reducing the mortality.

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Rodenticide poisoning in children: A study of clinical profile and electrocardiographic changes

Cited by 5 publications

References 10 publications

A cross-sectional study of the clinical profile of children admitted with yellow phosphorous poisoning in a tertiary care hospital

A cross-sectional study of the clinical profile of children admitted with yellow phosphorous poisoning in a tertiary care hospital

A Study on Ecg Findings in Acute Liver Cell Failure Due to Rat Killer Paste Poisoning

A study on outcome of rodenticide poisoning patients admitted to a tertiary care teaching hospital in relation to the chemical content of that poison

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