Roentgenology-pathology correlative study of neovascularity

Gammill, S. L.; Shipkey, FH; Himmelfarb, EH; Parvey, LS; Rabinowitz, JG

doi:10.2214/ajr.126.2.376

Cited by 41 publications

(12 citation statements)

References 10 publications

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“…Although conventional B‐mode imaging has a higher spatial resolution than Doppler US, the Doppler technique in its various applications has the potential to determine the propensity towards malignancy, by demonstrating blood vessel architecture, and measuring blood flow parameters in or surrounding the tumor 6,7 . Characteristic vessel morphology that may be detected with ultrasound, and thereby enable a presumptive diagnosis of malignancy, includes: irregular lumen, branching patterns, intervascular shunts, and blind‐ending vessels 6,8–19 . Nonmalignant angiogenesis is characterized by the development of an orderly arrangement of branching arteries.…”

Section: Tumor Angiogenesis and Its Relevance To Us Imagingmentioning

confidence: 99%

“…The endothelium is altered and vessels tend to leak. High molecular weight substances therefore diffuse more readily into the interstitial space than they do from anormal vascular bed 10,16,24 . Fibrinogen, for example, leaks through this abnormal endothelium and gives rise to fibrin deposits that can be found around certain tumors 25 .…”

Section: Tumor Angiogenesis and Its Relevance To Us Imagingmentioning

confidence: 99%

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A Review of the Sonographic Assessment of Tumor Metastases in Liver and Superficial Lymph Nodes

Nyman¹,

Kristensen²,

Flagstad³

et al. 2004

Vet Radiology Ultrasound

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Diagnostic imaging techniques are an important part of the diagnostic workup and staging of cancer patients. Ultrasound is of particular interest in this respect. In so far as tumor metastases are concerned, ultrasonography of regional lymph nodes and of the liver can provide valuable information. In humans many criteria, some of them objective, have been evaluated as indicators of malignancy. The most diagnostically helpful of these include the short/long axis ratio of the lymph node, the pattern of distribution of the blood vessels within the lymph node, and to some extent the calculated values for resistive and pulsatility indices. Putative objective criteria to improve the specificity of ultrasound for metastases detection in the liver have also been evaluated. These include perfusion indices, primarily using analysis of Doppler frequencies (Doppler perfusion index) and hepatic venography using an ultrasound contrast agent. Contrast-enhanced ultrasonography is a new and promising area to help the initial diagnosis and characterization of malignancy, particularly for focal lesions in the liver. This review discusses the use of ultrasound for detection of metastases and presents material from four veterinary cases.

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Section: Tumor Angiogenesis and Its Relevance To Us Imagingmentioning

confidence: 99%

Section: Tumor Angiogenesis and Its Relevance To Us Imagingmentioning

confidence: 99%

A Review of the Sonographic Assessment of Tumor Metastases in Liver and Superficial Lymph Nodes

Nyman¹,

Kristensen²,

Flagstad³

et al. 2004

Vet Radiology Ultrasound

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“…Malignant tumors develop neovascularity shown as bizarre vessels with an irregular course, arteriovenous shunting, tumor blush and tumor lakes 14 . Doppler ultrasound has been used to detect tumor vascularity in the various fields.…”

Section: Discussionmentioning

confidence: 99%

Adrenal adenoma mimicking a submucosal tumor of the stomach

Shudo

Yazaki

Sakurai

et al. 2001

Digestive Endoscopy

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The widespread use of diagnostic imaging modalities has increased the incidental detection of adrenal masses. We experienced a case of adrenal adenoma that was detected incidentally on mass X‐ray examination of the stomach, with findings that were initially suggestive of a gastric submucosal tumor. Only a few cases of adrenal adenoma that resembles a gastric submucosal tumor on diagnostic imaging have been reported. In addition, only a few papers have described the endoscopic ultrasonography findings of adrenal tumors. As the preoperative endoscopic ultrasonography findings of the tumor in our patient correspond with the features of the cut surface of the resected tumor, endoscopic ultrasonography appears to be useful as a new imaging technique in the diagnosis of adrenal adenoma. As endoscopic ultrasonography is minimally invasive, it can be performed in an outpatient setting to collect useful information. As adrenal tumors can be visualized relatively easily, the presence of adrenal lesions should also be searched for when endoscopic ultrasonography is performed for biliary or pancreatic disorders.

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“…Although the classic imaging modality for demonstrating tumor neovascularity is angiography (STRICKLAND 1959;GAMMILL et al 1976;MAEDA 1979), its use is limited by its invasiveness, and it is therefore reserved for patients in whom therapeutic intervention is needed. Many of the features of tumor neovascularity can be imaged noninvasively with color or power Doppler sonography and wideband harmonic imaging.…”

Section: Vascular Morphologymentioning

confidence: 99%