Rofecoxib Versus Magnesium Sulfate to Arrest Preterm Labor: A Randomized Trial

McWhorter, Jeannie; Carlan, S. J.; O’Leary, Timothy D.; Richichi, Kris; O’Brien, William F.

doi:10.1097/01.aog.0000124784.48287.15

Cited by 37 publications

(13 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…600,605 Rescue tocolysis was employed in eight studies. 595,[598][599][600][601]603,605,607 One additional study examined a COX inhibitor (sulindac) for the prevention of recurrence of spontaneous preterm birth (Figures 218, 222) 610 a second additional study compared a COX-2 inhibitor (rofecoxib) with placebo in prevention of spontaneous preterm birth in high-risk women (Figures 226, 234) 609 and the remaining additional study compared the use of another NSAID (aspirin) with placebo in prevention of spontaneous preterm birth labour in the general population (Figures 227, 230, 235). 608 …”

Section: Figure 195 Forest Plot Of the Effects Of Calcium Channel Antmentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

View full text Add to dashboard Cite

For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

show abstract

Section: Figure 195 Forest Plot Of the Effects Of Calcium Channel Antmentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

View full text Add to dashboard Cite

show abstract

“…The results were considered as promising [804]. Rofecoxib per os and intravenous magnesium sulphate were similarly effective in delaying delivery in women in PTL between 22 and 34 weeks (n = 214) [805]. Rofecoxib had less maternal but similar incidence of neonatal side effects to magnesium sulphate [805].…”

Section: Selective Cox-2 Inhibitorsmentioning

confidence: 98%

Preterm Birth: A Review

Schellenberg

2006

CWHR

View full text Add to dashboard Cite

Preterm birth at less than 37 weeks gestation is a substantial burden to the community, representing a major source of infant death, severe handicap, and suffering for both victims and their families. Despite considerable research, little progress has been made in its prevention, partly because preterm birth is the endpoint of a silent multifactorial syndrome which begins long before labour starts. Infectious inflammation often plays a central role, but maternal susceptibility is probably also critical. Although progestogen treatment is preventive in some women with a prior history of preterm birth this will have little impact on the overall preterm birth rate unless effective treatment can be used in a much larger population of at risk women. An accurate screening test to identify such women is needed. The discovery of a screening test and of novel treatments requires a better understanding of the underlying biomolecular events. This paper gives an overview of the physiology and molecular biology of normal and abnormal pregnancy and parturition, the causes and consequences of preterm birth, and the difficulties of predicting and preventing preterm birth.

show abstract

“…[595][596][597][598][599][600][601][602][603][604][605][606][607] A further three RCTs were added when the searches were updated and expanded to include all NSAIDs. [608][609][610] The quality of the studies included in the review and of the additional studies was generally high (Figure 215).…”

Section: Figure 179 Forest Plot Of the Effects Of Betamimetics Versusmentioning

confidence: 99%

“…The studies included in the review examined NSAIDs and COX inhibitors for treating threatened preterm labour. [595][596][597][598][599][600][601][602][603][604][605][606][607] Data were available on the following comparisons: 216,218,219,222,223,226,228,231,234 …”

Section: Figure 179 Forest Plot Of the Effects Of Betamimetics Versusmentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

2010

Clinical Governance: An International Journal

View full text Add to dashboard Cite

How to obtain copies of this and other HTA programme reports An electronic version of this publication, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable CD-ROM is also available (see below).Printed copies of HTA monographs cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our Despatch Agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in t...

show abstract

Rofecoxib Versus Magnesium Sulfate to Arrest Preterm Labor: A Randomized Trial

Abstract: There was no difference between oral rofecoxib and intravenous magnesium sulfate in arresting preterm labor.

Cited by 37 publications

References 41 publications

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Preterm Birth: A Review

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Contact Info

Product

Resources

About