This work proposes a scalable architecture of an Uninterruptible Power Supply (UPS) system, with predictive diagnosis capabilities, for safety critical applications. A Failure Mode and Effect Analysis (FMEA) has identified the faults occurring in the energy storage unit, based on Valve Regulated Lead-Acid batteries, and in the 3-phase high power transformers, used in switching converters and for power isolation, as the main bottlenecks for power system reliability. To address these issues, a distributed network of measuring nodes is proposed, where vibration-based mechanical stress diagnosis is implemented together with electrical (voltage, current, impedance) and thermal degradation analysis. Power system degradation is tracked through multi-channel measuring nodes with integrated digital signal processing in the transformed frequency domain, from 0.1 Hz to 1 kHz. Experimental measurements on real power systems for safety-critical applications validate the diagnostic unit.