Role and benefits of exercise in the management of patients with heart failure

Keteyian, Steven J.; Fleg, Jerome L.; Brawner, Clinton A.; Piña, Ileana L.

doi:10.1007/s10741-009-9157-7

Cited by 21 publications

(21 citation statements)

References 80 publications

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“…One tested strategy is exercise/endurance training. In HF patients, exercise training seemed safe, increased mitochondrial inner surface membrane, improved exercise capacity, helped to attenuate abnormal HF pathophysiology and yielded a modest reduction in clinical events 7 . However, the use of exercise as a means to improve mitochondria structure can be problematic in patients with physical limitations thus, the need to identify alternate and safe strategies that trigger such effects.…”

Section: Discussionmentioning

confidence: 99%

Alterations in Skeletal Muscle Indicators of Mitochondrial Structure and Biogenesis in Patients with Type 2 Diabetes and Heart Failure: Effects of Epicatechin Rich Cocoa

Taub

Ramírez-Sánchez

Ciaraldi

et al. 2011

Clinical Translational Sci

108

105

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Abstract(-)-Epicatechin (Epi), a fl avanol in cacao stimulates mitochondrial volume and cristae density and protein markers of skeletal muscle (SkM) mitochondrial biogenesis in mice. Type 2 diabetes mellitus (DM2) and heart failure (HF) are diseases associated with defects in SkM mitochondrial structure/function. A study was implemented to assess perturbations and to determine the effects of Epi-rich cocoa in SkM mitochondrial structure and mediators of biogenesis. Five patients with DM2 and stage II/III HF consumed dark chocolate and a beverage containing approximately 100 mg of Epi per day for 3 months. We assessed changes in protein and/or activity levels of oxidative phosphorylation proteins, porin, mitofi lin, nNOS, nitric oxide, cGMP, SIRT1, PGC1␣, Tfam, and mitochondria volume and cristae abundance by electron microscopy from SkM. Apparent major losses in normal mitochondria structure were observed before treatment. Epi-rich cocoa increased protein and/or activity of mediators of biogenesis and cristae abundance while not changing mitochondrial volume density. Epi-rich cocoa treatment improves SkM mitochondrial structure and in an orchestrated manner, increases molecular markers of mitochondrial biogenesis resulting in enhanced cristae density. Future controlled studies are warranted using Epi-rich cocoa (or pure Epi) to translate improved mitochondrial structure into enhanced cardiac and/or SkM muscle function.

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Section: Discussionmentioning

confidence: 99%

Alterations in Skeletal Muscle Indicators of Mitochondrial Structure and Biogenesis in Patients with Type 2 Diabetes and Heart Failure: Effects of Epicatechin Rich Cocoa

Taub

Ramírez-Sánchez

Ciaraldi

et al. 2011

Clinical Translational Sci

108

105

View full text Add to dashboard Cite

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“…Additional reasons for the lack of improvement in endothelium-independent vasodilation may be inadequate delivery of blood to exercising skeletal muscle and reduced muscle sensitivity to nitric oxide [26]. The first point has been widely addressed in the literature [4,25]. Regarding the latter, investigators have suggested that the response of vascular smooth muscle in individuals who regularly take nitrate-based medications may attenuate to NO-mediated and cyclic guanosine monophosphate (cGMP) stimuli [27].…”

Section: Discussionmentioning

confidence: 99%

“…Nitrate use may need to be a consideration when using endothelium-independent vasodilation as an outcome variable. Finally, it is thought that the loss of endothelium-dependent vasodilation occurs early in the development of cardiovascular disease, but it is not clear if and when endothelium-independent vasodilation is reduced [24,25]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Exercise Interventions on Peripheral Vascular Endothelial Vasoreactivity in Patients with Heart Failure with Reduced Ejection Fraction

Vuckovic

Piano

Phillips

2013

Heart, Lung and Circulation

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Changes in vascular function, such as endothelial dysfunction are linked to the progression of heart failure (HF) and poorer outcomes, such as increased hospitalisations. Exercise training may positively influence endothelial function in HF patients with reduced ejection fraction. The aim of this manuscript is to summarise HF studies evaluating the influence of exercise training on endothelial function as measured by flow mediated vasodilation as a primary outcome and to provide recommendations for future research studies designed to improve peripheral vascular function in HF. Databases were searched for studies published between 1995 and December 2011. Two reviewers determined eligibility and extracted information on study characteristics and quality, exercise interventions, and endothelial function. Eleven articles (N = 318 HF participants with an ejection fraction <40%) were eligible for full review. Aerobic, resistance, or combined exercise training improved endothelium-dependent vasodilation as measured by ultrasound or plethysmography. There is less evidence supporting improvement in endothelium-independent function with exercise training. Sample sizes were small and predominantly male. Future research is needed to address the best mode and optimal dose of exercise for all patients with HF including women and subgroups with specific co-morbidities.

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“…Endurance exercise training represents an effective way to provide relatively safe, non‐pharmacological therapy for mitigating subclasses of cardiac diseases (Keteyian et al . , ; Belardinelli et al . ), including lethal ventricular arrhythmias (Billman, ).…”

Section: Structural and Functional Organization Of The Cardiac Nervoumentioning

confidence: 99%

Translational neurocardiology: preclinical models and cardioneural integrative aspects

Ardell

Andresen

Armour

et al. 2016

The Journal of Physiology

151

178

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Neuronal elements distributed throughout the cardiac nervous system, from the level of the insular cortex to the intrinsic cardiac nervous system, are in constant communication with one another to ensure that cardiac output matches the dynamic process of regional blood flow demand. Neural elements in their various 'levels' become differentially recruited in the transduction of sensory inputs arising from the heart, major vessels, other visceral organs and somatic structures to optimize neuronal coordination of regional cardiac function. This White Paper will review the relevant aspects of the structural and functional organization for autonomic control of the heart in normal conditions, how these systems remodel/adapt during cardiac disease, and finally how such knowledge can be leveraged in the evolving realm of autonomic regulation therapy for cardiac therapeutics.

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Role and benefits of exercise in the management of patients with heart failure

Cited by 21 publications

References 80 publications

Alterations in Skeletal Muscle Indicators of Mitochondrial Structure and Biogenesis in Patients with Type 2 Diabetes and Heart Failure: Effects of Epicatechin Rich Cocoa

Alterations in Skeletal Muscle Indicators of Mitochondrial Structure and Biogenesis in Patients with Type 2 Diabetes and Heart Failure: Effects of Epicatechin Rich Cocoa

Effects of Exercise Interventions on Peripheral Vascular Endothelial Vasoreactivity in Patients with Heart Failure with Reduced Ejection Fraction

Translational neurocardiology: preclinical models and cardioneural integrative aspects

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