"Role and Correlation of Laboratory Biomarkers in the Assessment of Severe COVID-19 in Children"

Abstract

At the end of 2019, the coronavirus infection quickly spread around the world and WHO declared the beginning of a pandemic on March 11, 2020. To this end, the authors decided to study the role of some laboratory biomarkers in assessing the severity of the course of the disease Covid-19 in children and the correlation between them. 551 patients applied to the Department of Pediatric Infectious Diseases. 55 patients without comorbidity, with confirmed "Upper Respiratory Diseases" were treated on an outpatient basis and entered the control group. 496 patients were diagnosed with Covid-19 and were included in the study group. Of the patients, 364 children were laboratory positive for C-19 and belonged to group I (covid pediatric). Laboratory C-19 in 132 children was assigned to the negative-II group (MIS-Ch). Patients were diagnosed with a number of biomarkers (inflammatory, respiratory and metabolic panel, coagulogram, interleukin-6, brain natriuretic peptide concentration) in the blood and the correlation between them. When comparing patients of groups I and II, it was found that the concentration of biomarkers was higher in patients of group II. This once again proves that the Covid-19 disease is more severe in patients of group II. In both groups, the correlation coefficient between biomarkers was also studied. Thus, there is a direct strong correlation between creatine kinase-MB and ferritin in group I and BNP and interleukin-6 in group II, and it is statistically significant.