Aspects of ensuring eco-safe development of regions are considered. The essential content of the concept of "ecological safety", principles and directions of ensuring eco-safe development of the territory are analyzed. Special attention is paid to substantiating the need to ensure the innovation orientation of this development in the context of the formation of such institutional forms of in-teraction of parties interested in ensuring the effectiveness of this process, as eco-innovation clus-ters and eco-technoparks.