Role and Side Effects of Topical Phenytoin Dressing in Diabetic Foot Ulcer as Compared to Conventional Betadine Dressing

Yadwadkar, Dr Shrirang

doi:10.18535/jmscr/v3i12.52

Cited by 3 publications

(6 citation statements)

References 7 publications

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“…In this study, phenytoin displayed better and more reliable outcomes for BDD care within 14 days of treatment, as shown by the substantially improved scores of lesion depth, size, and clinical findings. These results are consistent with the previous studies on both humans and rodents [ 12 - 14 ]. The influence of phenytoin on treating DD might be attributed to an increase in fibroblast proliferation, which, in turn, hinders the action of collagenase, encourages collagen deposition, improves the formation of granulation tissue, reduces bacterial contamination, and thus limits the formation of wound exudates [ 12 , 13 ].…”

Section: Discussionsupporting

confidence: 94%

“…The influence of phenytoin on treating DD might be attributed to an increase in fibroblast proliferation, which, in turn, hinders the action of collagenase, encourages collagen deposition, improves the formation of granulation tissue, reduces bacterial contamination, and thus limits the formation of wound exudates [12,13]. Importantly, the low cost and ease of use of phenytoin make it a good candidate for clinical use [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, searching for more safe and cost-efficient drugs to treat DD in dairy cows is urgently required. In this regard, phenytoin (diphenylhydantoin) is a commercially available local dressing agent used for improving wound and ulcer healing in humans and various animal species [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows

et al. 2021

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Background and Aim: Digital dermatitis (DD) is one of the most common causes of lameness in dairy cattle. It is seen in nearly all dairy herds across the world and has substantial welfare and economic implications. In this study, we aimed to investigate the efficacy of phenytoin sodium topical treatment on painful ulcerative stage of bovine digital dermatitis (BDD). Materials and Methods: In total, 45 Holstein-Friesian dairy cows with DD were randomly assigned to one of the three topical treatment trials (15 each): Saline solution (first treatment, negative control), chlortetracycline spray (second treatment, positive control), or phenytoin sodium powder (third treatment, positive control) (third treatment). On day 0 (pre-treatment) and on days 7, 14, 21, and 28 post-treatment, the response of DD-affected cows to the medications used was evaluated by measuring lesion depth and size, as well as the total clinical score (lameness, pain, and discomfort). Results: The cure rate in cows treated with phenytoin (86.66%) on day 28 was significantly improved compared to cows treated with either chlortetracycline (60%) or normal saline (6.66 %). Conclusion: Our findings highlight the superiority of phenytoin over the commonly used antibacterial agent, chlortetracycline, in the topical treatment of BDD, and subsequently suggest that phenytoin should be considered a suitable alternative treatment option for the treatment of BDD.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows

et al. 2021

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“…Vardhan A [13] et al also had most cases in 51-60 yr which were 50% cases. Yadwadkar S [14] et al also had most of cases in 51-60 yrs which were 44% of cases. Our results were slightly higher as compared to these studies.…”

Section: Discussionmentioning

confidence: 91%

Role of topical phenytoin (Diphenylhydantoin) dressing in diabetic ulcers: A comparative study with conventional dressing

Sandhu¹,

Singh²,

Banga³

et al. 2018

Int. J. Orthop. Sci.

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Introduction:The stimulatory effect of phenytoin on connective tissue suggested possibility for its use in wound healing. Oral phenytoin was first introduced as an antiseizure medication in 1937. Over 60 years investigators have shown an interest in how topical phenytoin may be used to promote wound healing in a variety of chronic wounds. Materials and Methods: A sample of 40 patients with diabetic ulcers was selected using purposive sampling technique. The patients were divided into two groups: Group A (Phenytoin group) (n=20) and Group B (conventional group) (n=20). In Group A, the patient's dressing were done using phenytoin and in Group B, with povidine. The patients were followed up on a daily basis for 9 days in both study and control groups. Wound culture was obtained at the start of the treatment and on the 7 th day of treatment. Then the patients were subjected to split thickness skin grafting on 10 th day. The follow up of the patients were done at one month after discharge in outpatient department for post skin grafting complications. Result: The mean duration of hospital stay in phenytoin group was 21.35±4.71 (SD) days and that in the conventional group was 27.3±6.48 (SD) days. One month follow up complications in conventional group were more as compared to phenytoin group. Conclusion: Topical phenytoin dressing helps in better granulation tissue formation and better graft take up than the conventional dressing. Hospital stay and post-operative complications were less in topical phenytoin dressing group as compared to conventional dressing group. Conflict of interest: Nil Source of funding: Nil

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“…After diabetic gangrene developed, the hind limbs of rats were observed and evaluated on day 0, day 7, and day 14 visually and characterized by the Wagner-Meggit scale. Macroscopic observed include wound, edema, redness, and red to dark color as a sign of diabetic gangrene (Yadwadkar, 2016).…”

Section: Macroscopic Observationmentioning

confidence: 99%

The Antigangrene Activity of Transdermal Patch of Insulin Leaves (Smallanthus Sonchifolius) to Diabetic Gangrene on White Rats

Hendriati

Fredericktho

Hamid

et al. 2022

JFG

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Background: Diabetic gangrene is a chronic complication of diabetes mellitus caused by neuropathy, blood vessel disorders, and infection by Staphylococcus aureus. S.sonchifolius leaves contains flavonoid as hypoglycemic agents and sesquiterpene lactones as antibacterial. Unfortunately, oral administration of S. sonchifolius leaves infusion causes kidney toxicity. Objective: The aimed of the study was to determine the effectiveness of the transdermal patch of S. sonchifolius leaves ethanol extract on gangrene wound healing with macroscopic parameters and neoangiogenesis of gangrenous wounds in white rats that have been induced by diabetes mellitus. Material and Methods: This study used 4 treatment groups: positive control (Bevalex® cream), negative control (patch without S. sonchifolius leaves extract), F1 (S. sonchifolius leaves patch without enhancer), and F2 (S. sonchifolius leaves patch with Tween 60 as enhancer). The dose of S. sonchifolius leaves given was 400 mg/kg BW. Alloxan-induced diabetic rat feet were injected with S. aureus to form gangrene. Observations were made on the 7th and 14th days. Results: Based on the Wagner-Meggit scale on macroscopic observations, administration of a transdermal patch of S. sonchifolius leaves accelerates gangrene healing. The statistical results of neoangiogenesis on the 7th and 14th days showed a significant difference (p<0.05) between the positive control, F1, and F2 to the negative control. F2 showed the highest angiogenesis on day 7 (114.00 ± 5,00) and 14 (161.00 ± 5.29) compared to all groups. Tween 60 as enhancer increase the number of angiogenesis. Both F1 and F2 did not show a significant difference to the positive control. Conclusion: S. sonchifolius leaves ethanol extract patch accelerated the diabetic gangrene healing process based on macroscopic and neoangiogenesis observation on the 7th and 14th days. Toxicity examination in white rats are needed before clinical study in human.

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Role and Side Effects of Topical Phenytoin Dressing in Diabetic Foot Ulcer as Compared to Conventional Betadine Dressing

Cited by 3 publications

References 7 publications

Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows

Phenytoin: A promising non-antibiotic drug for the topical treatment of digital dermatitis in dairy cows

Role of topical phenytoin (Diphenylhydantoin) dressing in diabetic ulcers: A comparative study with conventional dressing

The Antigangrene Activity of Transdermal Patch of Insulin Leaves (Smallanthus Sonchifolius) to Diabetic Gangrene on White Rats

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