Rôle d'une eau sulfatée calcique et magnésienne sur l'élimination du cholestérol chez le rat

Abstract

In the rat, the activity of the thermal water of Capvern and of its ionic components on the modification of the flow rate and composition of hepatic bile has been investigated. Two groups of rats were selected: the first group received per os an overload of the thermal water during six weeks. At that time on empty stomach a great increase of biliary phospholipids was observed. An intraduodenal injection of the thermal water produced a significant and rapid increase of biliary flow rate and biliary cholesterol. the animals of the second group received through intraduodenal injections the thermal water or an anionic solution composed of calcium, of magnesium sulphate or of both salts at their concentration in the thermal water, respectively. We observed an increase in biliary flow rate and biliary calcium concentration in the rats receiving the solution of calcium sulphate only and an increase of choleresis in the rats receiving the thermal water only. These data suggest that the thermal water has a specific action on the metabolism of cholesterol in increasing its biliary elimination particularly through the calcium ion content of the water.

Drinking mineral waters: biochemical effects and health implications the state-of-the-art

“…Among the various non-pharmacological tools for controlling cholesterolaemia, besides a low cholesterol diet, hydropinic treatment with mineral waters of a particular chemical-physical composition can be used. Hydropinic therapy with sulphate-alkaline spring water has been shown capable of markedly reducing increased cholesterolaemic and lipaemic levels by increasing the lipoprotein metabolism (Toussaint et al, 1986(Toussaint et al, , 1988. In particular, studies carried out on the effect of the spring mineral water from Montecatini (Italy) on bile acid extraction and lipid and apolipoprotein serum levels suggested that salt-rich spring water treatment reduces serum-and LDL-cholesterol levels in subjects with mild hypercholesterolaemia, through a mechanism of increased excretion of faecal bile acid sterols (Foschi and Arena, 1990).…”

“…Literature reports have demonstrated that this type of water, which contains SO4 2 , Ca 2+ and Mg 2+ ions, has a very good hypocholesterolaemic activity, because it is able to decrease the Low-Density Lipoprotein (LDL) level in blood. Toussaint et al (1986Toussaint et al ( , 1988 suggested that, in rats, salt-rich mineral waters enhance the conversion of cholesterol into bile acids and their subsequent secretion. Analogous studies on humans reported important effects of various mineral waters, mostly fizzy bicarbonated mineral waters, on lipoprotein levels (Sharma et al, 1990;Schoppen et al, 2004).…”

“…The few available biochemical studies showed the effects on animal models and human. Spring mineral waters have antioxidant, hypocholesterolaemic activity and may affect calcium metabolism (Toussaint et al, 1986(Toussaint et al, , 1988. For example, sulphurous mineral water was found to have anti-oxidant properties and a positive effect on the oxidative defence mechanism on both rabbits and rats, respectively (Albertini et al, 1996(Albertini et al, , 1999a.…”

“…The oral intake of water containing calcium increases serum calcium and inhibits intact parathyroid hormone secretion (Cantalamessa and Nasuti, 2003). However, results vary depending on the type of water mineralisation (Toussaint et al, 1988;Aptel, Cance-Rouzaud and Grandjean, 1999;Neimark, Davvdov and Lebedev, 2003;Nerbrand et al, 2003). Epidemiological studies carried out over the past 10 years found the relations between the mineral content of drinking water and the Cardiovascular Disease (CVD) mortality rate in various countries (Sauvant and Pepin, 2000;Schoppen et al, 2004).…”

Erythrocyte Plasma Membrane Perturbations in Rats Fed a Cholesterol-Rich Diet: Effect of Drinking Sulphurous Mineral Water

“…The hydropinic treatment was carried out using a calcic and magnesic-sulphate-sulphurous spring mineral water called 'San Giovanni' and indicated by us as sulphurous mineral water (SMW). Literature reports have demonstrated that this type of water, which contains SO 4 -, Ca 2+ and Mg 2+ ions, has a very good hypocholesterolaemic activity, because it is able to decrease the low-density lipoprotein level in blood [11] .…”