Role of 1–123 serum amyloid Srotein in the etection of familial amyloidosis in Oriental cats

Piirsalu, K.; McLean, Robert H.; Zuber, Richard M.; Bannistert, K.; Penglis, S.; Bellen, Johan C.; Bais, Renz

doi:10.1111/j.1748-5827.1994.tb03824.x

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…Since affected cats are often related, the relative contribution of genetic and environmental factors has been difficult to determine. The predominance of Siamese or their colour variants (Oriental and foreign shorthair), coupled with pedigree analyses, have led to the suggestion that this systemic amyloidosis may be a familial trait in Siamese and related breeds (Piirsalu andothers 1994, van der Linde-Sipman andothers 1997).…”

Section: Introductionmentioning

confidence: 99%

Spontaneous hepatic rupture in six cats with systemic amyloidosis

Beatty

Barrs

Martín

et al. 2002

J of Small Animal Practice

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Spontaneous hepatic rupture, secondary to the accumulation of hepatic amyloid, was diagnosed in six cats over a two-year period. Previous reports of feline hepatic amyloidosis have documented clusters of cases from breeding catteries. Most affected cats have been Siamese or a related breed and the disease is generally regarded as familial. In contrast, the cases presented here were sporadic, with relatives and other cats in the household not clinically affected. They included a Devon rex, a breed not previously reported with this condition, and a domestic shorthair. Clinical signs in three of these cases had, prior to referral, been misinterpreted as resulting from blunt trauma, immune-mediated haemolysis or a coagulopathy. Antemortem diagnostic features, including new data on the value of hepatic ultrasonography and fine-needle aspirate cytology, are reported. These cases illustrate how the course of this disease can vary between individuals and that, despite the dramatic underlying pathology, hepatic amyloidosis can present a diagnostic challenge and should be suspected in any young adult cat with consistent clinical signs, irrespective of breed or environment.

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Section: Introductionmentioning

confidence: 99%

Spontaneous hepatic rupture in six cats with systemic amyloidosis

Beatty

Barrs

Martín

et al. 2002

J of Small Animal Practice

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“…Thus, failure of staining of dog and cat amyloid could indicate that SAP does not accumulate here. However, I‐123 labelled human SAP accumulates in amyloid‐affected livers of Oriental cats (Piirsalu et al., 1994); the type of amyloid was not determined, but was probably AA. A more plausible explanation of the lack of staining is that the anti‐human SAP antibody does not react with SAP in the two species.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Identification of Amyloid, Using an Anti‐human Serum Amyloid P Component (SAP) Antibody, is Possible in Ruminants but not in Dogs and Cats

Härtig

Leifsson

Nielsen

2005

Journal of Veterinary Medicine Series A

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Amyloidosis represents a heterogenous group of diseases that have in common the deposition of fibrils composed of proteins of beta-pleated sheet structure, a structure which can be specifically identified by histochemistry using the Congo red or similar stains. Amyloid consists primarily of the amyloid fibrils but also of the amyloid P component (AP). This component, which is identical with the serum counterpart (SAP), is found in all types of human amyloid, and immunohistochemical identification of AP has been proposed as an adjunct to the universal, type-independent diagnosis of human amyloidosis. In the present study of animal amyloidosis, we compared the amyloid-specific Congo red stain with an immunohistochemical protocol using an anti-human SAP antibody for the identification of amyloid in formalin fixed tissue samples. The species and types of amyloidoses investigated were: (i) seven cows, one yak (Bos grunniens), and one sheep affected with amyloidosis of presumed AA type, (ii) one dog with a pancreatic endocrine tumour producing amyloid of presumed AIAPP type, (iii) two cats with presumed AIAPP-amyloidosis of the islets of Langerhans, one cat with presumed AA-amyloidosis, and one cat with an amyloid-producing odontogenic tumour. Intense immunostaining co-localized with amyloid, identified by its congophilia and green birefringence, using a protocol without any antigen retrieval in each of the seven cows, the yak and the sheep. The method seemed more sensitive in the ruminants than the Congo red stain, but was unable to detect amyloid in the dog and the cats regardless of the application of various antigen retrieval protocols. However, specific identification of amyloid still rests on the Congo red method or similar histochemical techniques.

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2018

Breed Predispositions to Disease in Dogs and Cats

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Role of 1–123 serum amyloid Srotein in the etection of familial amyloidosis in Oriental cats

Cited by 8 publications

References 16 publications

Spontaneous hepatic rupture in six cats with systemic amyloidosis

Spontaneous hepatic rupture in six cats with systemic amyloidosis

Immunohistochemical Identification of Amyloid, Using an Anti‐human Serum Amyloid P Component (SAP) Antibody, is Possible in Ruminants but not in Dogs and Cats

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