Role of 10000-Fold Effect in Improving Urodynamic Parameters with Supra Spinal Cord Injury

Tewari, Vinod Kumar; Johari, Devesh; Tewari, Lori; Neeraj, ..

doi:10.31080/asne.2020.03.0266

Cited by 1 publication

(1 citation statement)

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“…Tewari et al [13] In the present study, we observed mild to moderate and tolerable adverse events in Tadalafil group and the participants did not require any pharmacological treatments or hospitalization for these adverse events. Reported adverse events in the Tadalafil group were as follows: 11 (33.3%) individuals complained of mild headache, 9 (27.3%) had muscle ache, 1 (3%) had vomiting, and 16 (48.5%) had nausea whereas six did not complain any side effect.…”

Section: Resultssupporting

confidence: 66%

To Study the Effect of Tadalafil in Improving Urodynamic Parameters in Spinal Cord Injury Patients: A Randomized Controlled Trial

KARMENDRA SINGH KUSHWAHA,

OM PRAKASH,

NIKHIL AGARWAL

et al. 2024

Asian J Pharm Clin Res

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Objectives: The aim of the study was to compare the effect of single dose Tadalafil 20 mg 2 h after administration on Urodynamic study (UDS) parameters and comparison with calcium+vit-D3 (control) in spinal cord injury (SCI). Methods: Sixty-six SCI individuals with lower urinary tract symptoms (LUTS) and upper motor neuron bladder were randomized into Tadalafil group (n=33) and calcium+vitD3 group (n=33). UDS was done and parameters (maximum detrusor filling pressure [MDFP], maximum bladder capacity, and bladder compliance) were recorded at baseline and 2 h after administration of respective drugs in both groups and comparison was done. Results: Statistically significant improvement in mean MDFP from 24.42±6.75 to 21.12±5.72 cm H2O (p < 0.001), mean maximum bladder capacity from 263.94±108.48 to 287.67±112.71 mL (p<0.001), and mean bladder compliance from 11.07±4.31 to 13.94±5.13 mL/cm H2O (p<0.001) was observed in Tadalafil group whereas in calcium+vit-D3 group, no significant improvement was observed. When we compared difference of mean of MDFP, bladder capacity, and bladder compliance between Tadalafil and calcium+vitD3 group, significant improvement (p<0.001) in Tadalafil group was noted as compared to calcium+vitD3 group. Conclusions: Single dose of oral Tadalafil 20 mg has shown significant improvement in MDFP, bladder capacity, and bladder compliance in SCI individuals with LUTS as compared to control.

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Section: Resultssupporting

confidence: 66%