Role of 18F-FDG PET/CT <i>vs</i> CT-scan in patients with pulmonary metastases previously operated on for colorectal liver metastases

López-López, Víctor; Robles, R; Brusadín, Roberto; Conesa, Asunción López; Torres, Juan; Flores, Domingo Pérez; Navarro, José Luís; Álvarez, Pedro Gil; Parrilla, Pascual

doi:10.1259/bjr.20170216

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…Imaging is not only used for diagnosis and follow-up of lung metastases but can also support and guide local treatment such as thermal treatments (generally CT-guided), namely radiofrequency, microwave, cryotherapy [11]. Nuclear medicine, especially with radiologic imaging fusion—positron emission tomography-computed tomography (PET-CT) and positron emission tomography-magnetic resonance imaging (PET-MRI), allows the coupling of morphologic data from imaging with physiological data on the uptake of radiotracers [12].…”

Section: Clinical and Radiological Presentation Of Pulmonary Metasmentioning

confidence: 99%

Lung-Seeking Metastases

Stella

Kolling

Benvenuti

et al. 2019

Cancers

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Metastases from different cancer types most often affect the lung parenchyma. Moreover, the lungs are among the most frequent sites of growth of metastatic masses of uncertain/unknown lineage of origin. Thus, with regards to pulmonary neoplastic parenchymal nodules, the critical issue is to determine if they are IN the lung or OF the lung. In this review, we highlight the clinical, instrumental and molecular features which characterize lung metastases, mainly focusing on recently advancing and emerging concepts regarding the metastatic niche, inflammation, angiogenesis, immune modulation and gene expression. A novel issue is related to the analysis of biomechanical forces which cooperate in the expansion of tumor masses in the lungs. We here aim to analyze the biological, genetic and pathological features of metastatic lesions to the lungs, here referred to as site of metastatic growth. This point should be a crucial part of the algorithm for a proper diagnostic and therapeutic approach in the era of personalized medicine.

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Section: Clinical and Radiological Presentation Of Pulmonary Metasmentioning

confidence: 99%

Lung-Seeking Metastases

Stella

Kolling

Benvenuti

et al. 2019

Cancers

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“…In the present study, an increase in the use of ceMRI in the Netherlands was observed, whereas use of 18F-FDG PET-CT decreased. These trends are probably the result of international publications 4,7,8,10,12,13,15,31,34 reporting the additional value of these imaging modalities.…”

Section: Discussionmentioning

confidence: 99%

“…Detection rates are lower in patients who have received preoperative chemotherapy. One RCT investigated the additional value of 18 F‐FDG PET–CT in CRLM and concluded that this did not influence survival, whereas several unrandomized studies indicated that there could be added value for 18 F‐FDG PET–CT in patients with extrahepatic metastases.…”

Section: Discussionmentioning

confidence: 99%

Preoperative imaging for colorectal liver metastases: a nationwide population-based study

et al. 2020

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Background: In patients with colorectal liver metastases (CRLM) preoperative imaging may include contrast-enhanced (ce) MRI and [ 18 F]fluorodeoxyglucose (18 F-FDG) PET-CT. This study assessed trends and variation between hospitals and oncological networks in the use of preoperative imaging in the Netherlands. Methods: Data for all patients who underwent liver resection for CRLM in the Netherlands between 2014 and 2018 were retrieved from a nationwide auditing database. Multivariable logistic regression analysis was used to assess use of ceMRI, 18 F-FDG PET-CT and combined ceMRI and 18 F-FDG PET-CT, and trends in preoperative imaging and hospital and oncological network variation. Results: A total of 4510 patients were included, of whom 1562 had ceMRI, 872 had 18 F-FDG PET-CT, and 1293 had combined ceMRI and 18 F-FDG PET-CT. Use of ceMRI increased over time (from 9⋅6 to 26⋅2 per cent; P < 0⋅001), use of 18 F-FDG PET-CT decreased (from 28⋅6 to 6⋅0 per cent; P < 0⋅001), and use of both ceMRI and 18 F-FDG PET-CT 16⋅9 per cent) remained stable. Unadjusted variation in the use of ceMRI, 18 F-FDG PET-CT, and combined ceMRI and 18 F-FDG PET-CT ranged from 5⋅6 to 100 per cent between hospitals. After case-mix correction, hospital and oncological network variation was found for all imaging modalities. Discussion: Significant variation exists concerning the use of preoperative imaging for CRLM between hospitals and oncological networks in the Netherlands. The use of MRI is increasing, whereas that of 18 F-FDG PET-CT is decreasing. Funding information No funding * Members of the Dutch Hepato-Biliary Audit Group are co-authors and can be found under the heading Collaborators.

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“…18 F fluorodeoxyglucose PET/computed tomography ( 18 F-FDG PET/CT) imaging provides semiquantitative analysis of glucose uptake by lesions, and the degree of FDG uptake in lesions is often expressed as the standardized uptake value (SUV), with the maximum standardized uptake value (SUV max ) being the most commonly used metabolic parameter to assess tumor metastasis, determine staging and guide treatment. Compared to normal CT scans, the specificity of 18 F-FDG PET/CT for the diagnosis of CRLM is increased by 19%, and 18 F-FDG PET/CT can detect more CRLM lesions [8,9].…”

Section: Introductionmentioning

confidence: 99%

Analyzing the value of delayed 18F-FDG PET/CT images in diagnosing small colorectal cancer liver metastases in patients with hypothyroidism based on diagnostic accuracy and image standardized uptake value

Pei,

Wang,

Hao

et al. 2024

Nuclear Medicine Communications

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Purpose The objective of this study was to investigate the value of delayed 18F fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) images in patients with small colorectal cancer liver metastases (CRLMs) with hypothyroidism. Method We performed a retrospective analysis of 66 small-CRLM patients with hypothyroidism and 66 small-CRLM patients with euthyroidism, all of whom underwent dual-time-point 18F-FDG PET/CT imaging. First, the diagnostic accuracy of PET/CT early imaging and PET/CT delayed imaging on lesions was analyzed. Next, the correlation of metabolic parameters between PET/CT early imaging and PET/CT delayed imaging was analyzed according to the grouping of all lesions. Finally, PET/CT parameters were analyzed for correlation with thyroid hormones. Results The diagnostic accuracy of delayed imaging in small-CRLM patients with hypothyroidism is not as good as that in small-CRLM patients with euthyroidism; PET/CT metabolic parameters are also unfavorable for the diagnosis of small-CRLM. For small-CRLM patients with hypothyroidism, the greater the thyroid-stimulating hormone level, the greater the uptake of 18F-FDG in normal liver tissue, and the smaller the ratio of tumor lesion uptake to normal liver tissue uptake. Conclusion PET/CT-delayed imaging has better performance than early imaging in small-CRLM patients with euthyroidism. However, the more severe the hypothyroidism, the worse the diagnostic delayed imaging performance. The scan time can be extended appropriately to optimize the imaging efficacy.

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Role of 18F-FDG PET/CT vs CT-scan in patients with pulmonary metastases previously operated on for colorectal liver metastases

Cited by 7 publications

References 25 publications

Lung-Seeking Metastases

Lung-Seeking Metastases

Preoperative imaging for colorectal liver metastases: a nationwide population-based study

Analyzing the value of delayed 18F-FDG PET/CT images in diagnosing small colorectal cancer liver metastases in patients with hypothyroidism based on diagnostic accuracy and image standardized uptake value

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