Role of 18F-FDG PET/CT in Renal Cyst Infection

Ueda, Cristiane; Ono, Carla Rachel

doi:10.1007/s40134-018-0265-9

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Since the introduction of cost-efficient 68 Ge/ 68 Ga generators, labelling of various peptides such as 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaceticacid-1-NaI 3 -octreotide (DOTA-NOC), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaceticacid-1-Tyr 3 -octreotate (DOTA-TATE), and the peptidomimetic inhibitor of prostate specific membrane antigen (PSMA) with gallium-68 has been well described [7,[17][18][19]. 68 Ge/ 68 Ga generators have the advantage of a PET radionuclide being readily available as opposed to cyclotron produced radionuclides such as fluorine-18 and carbon-11.…”

Section: Theorymentioning

confidence: 99%

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An automated synthesis method for 68Ga-labelled ubiquicidin 29–41

Rubow

Ebenhan

et al. 2019

J Radioanal Nucl Chem

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Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29-41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [ 68 Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using the three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [ 68 Ga]Ga-NOTA-UBI for clinical infection imaging.

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Section: Theorymentioning

confidence: 99%

“…2-Deoxy-2-[ 18 F]fluoroglucose, ([ 18 F]FDG) has been widely used in the imaging of bacterial infections [7][8][9]. The low specificity of [ 18 F]FDG has been described as a major limitation.…”

Section: Introductionmentioning

confidence: 99%

An automated synthesis method for 68Ga-labelled ubiquicidin 29–41

Rubow

Ebenhan

et al. 2019

J Radioanal Nucl Chem

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“…Nevertheless, with the advent of PET, positron emitter-labeled molecules, such as fluorine-18 ( 18 F) and gallium-68 ( 68 Ga), began to be studied and developed due to the inherent advantages of this technique, such as superior spatial resolution compared to SPECT images [10][11][12]. In this sense, [ 18 F]F-fluorodeoxyglucose and [ 68 Ga]Ga-citrate have come to be used; however, they cannot discriminate between inflammatory and infectious processes, or distinguish them from oncological lesions [2,13,14].…”

Section: Introductionmentioning

confidence: 99%

Radiosynthesis Standardization and Preclinical Assessment of the [68Ga]Ga-DOTA-Ubiquicidin29-41: A Translational Study Targeting Differential Diagnosis of Infectious Processes

Miranda,

Fuscaldi,

Mejia

et al. 2023

Pharmaceuticals

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Human bacterial infections significantly contribute to the increase in healthcare-related burdens. This scenario drives the study of novel techniques for the early and precise diagnosis of infectious processes. Some alternatives include Nuclear Medicine- and Molecular Imaging-based strategies. However, radiopharmaceuticals that are available for routine assessments are not specific to differentiating infectious from aseptic inflammatory processes. In this context, [68Ga]Ga-DOTA-Ubiquicidin29-41 was synthesized using an automated module and radiochemical; in vivo and in vitro studies were performed. The radiopharmaceutical remained stable in saline (up to 180 min) and in rodent serum (up to 120 min) with radiochemical purities > 99 and 95%, respectively. Partition coefficient and serum protein binding at 60 min were determined (−3.63 ± 0.17 and 44.06 ± 1.88%, respectively). Ex vivo biodistribution, as well as in vivo microPET/CT images in mice, showed rapid blood clearance with renal excretion and reduced uptake in other organs in Staphylococcus aureus-infected animals. Higher uptake was observed in the target as compared to the non-target tissue (p < 0.0001) at 60 min post administration. The presented in-human clinical case demonstrates uptake of the radiopharmaceutical by Staphyloccocus aureus bacteria. These results indicate the potential of [68Ga]Ga-DOTA-Ubiquicidin29-41 as a radiopharmaceutical that can be obtained in a hospital radiopharmacy for the diagnosis of infectious processes using PET/CT.

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Diagnostic Performance of 18-Fluorodeoxyglucose Positron-Emission Tomography-Computed Tomography (18F-FDG PET-CT) in the Detection of Autosomal Dominant Polycystic Kidney Disease Cyst Infections: A Meta-Analysis

Chandramohan,

Simhadri,

Singh

et al. 2024

Cureus

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Diagnosing suspected renal or hepatic infections in autosomal dominant polycystic kidney disease (ADPKD) is difficult. Although 18-fluorodeoxyglucose positron-emission tomography-computed tomography ( 18 F-FDG PET-CT) is recommended to aid in the diagnosis, there is no consensus about its diagnostic accuracy. We aimed to investigate its diagnostic performance. To further assess this, we performed a meta-analysis. A comprehensive literature search screening of PubMed/MEDLINE, Embase, and Cochrane library databases through February 2024 was performed. Pooled sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and C-reactive protein (CRP) were estimated using the random effects model. Heterogeneity between studies was estimated using Cochran Q and I2 statistics. A total of seven studies were included in the final analysis. The pooled sensitivity of 18 F-FDG PET-CT in diagnosing kidney and hepatic cyst infection was 82.6% (95% CI: 73.8-88.9; I2 16.9%), specificity was 77.6% (95% CI: 66.7-85.7; I2 15.6%), PPV was 79.4% (95% CI: 62.4-89.9; I2 62.6%), and NPV was 81.3% (95% CI: 72.7-87.7; I2 0%). The mean CRP was 244.2 mg/L (95% CI: 209.1-279.1; I2 66%). The results showed that 18 F-FDG PET-CT demonstrated excellent pooled diagnostic performance in diagnosing renal and hepatic cyst infections in ADPKD.

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Role of 18F-FDG PET/CT in Renal Cyst Infection

Cited by 3 publications

References 38 publications

An automated synthesis method for 68Ga-labelled ubiquicidin 29–41

An automated synthesis method for 68Ga-labelled ubiquicidin 29–41

Radiosynthesis Standardization and Preclinical Assessment of the [68Ga]Ga-DOTA-Ubiquicidin29-41: A Translational Study Targeting Differential Diagnosis of Infectious Processes

Diagnostic Performance of 18-Fluorodeoxyglucose Positron-Emission Tomography-Computed Tomography (18F-FDG PET-CT) in the Detection of Autosomal Dominant Polycystic Kidney Disease Cyst Infections: A Meta-Analysis

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