Role of 18F-FDG PET/CT in evaluation of recently diagnosed breast cancer patients

Kamal, Ayat Mahmoud; Kamal, O.; Sakr, Hossam Moussa; Ali, Susan Adil

doi:10.1186/s43055-022-00866-1

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…Our results are also in line with a study of Gajjala et al [19] that examined 61 locally advanced breast cancer patients and declared that 18 F-FDG PET/CT staging had a higher accuracy than the conventional imaging staging. In the study of kamal et al [20], 50 women with newly diagnosed breast cancer showed higher diagnostic performance of 18 F-FDG PET/CT with % 100 sensitivity in comparison to 96 % sensitivity of contrast-enhanced CT. 18 Additionally, according to the NCCN guidelines, performing PET/CT examination may be more effective in detecting suspected nodal and distant metastatic involvement in locally advanced breast cancer stage III, but not advised for stage I, II, or operable III (T3 N1) breast cancer because of the high probability of false-negative results of the tiny lesions. The main limitation of this study was that it was performed at a single center as well as the relatively small sample size.…”

Section: Resultsmentioning

confidence: 94%

Role of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in evaluation of newly diagnosed breast cancer patients

Esmail,

Abdulsalam,

Khatab

et al. 2023

Zagazig University Medical Journal

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Background: People of various races, ages, financial backgrounds, and geographic areas are typically affected by breast cancer, which is the most common malignant disease in women. After a diagnosis of breast cancer, a precise assessment of tumor staging is necessary to establish the course of treatment and prognosis. Aim: To investigate the role of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) in staging, pre-therapeutic metastatic workup or preoperative evaluation of newly diagnosed patients with breast cancer which subsequently affects their management. Patients and methods: This prospective study included 30 female patients who were recently diagnosed as breast cancer and were referred for initial 18F-FDG PET/CT scans for preoperative or pre-therapeutic staging. All patients underwent both CT and PET examinations for initial staging of breast cancer. The reference standard was histopathology and 6-12 months follow-up. Results: PET/CT revealed higher sensitivity (92%) and specificity (80%) in diagnosis of nodal metastasis compared to conventional CT with lower sensitivity (64%) and specificity (60%). Also, PET/CT had higher sensitivity (94.4%) and specificity (75%) in diagnosis of distant metastasis compared to conventional CT with lower sensitivity (88.9%) and specificity (66.7%). Conclusions:The quick, accurate, and noninvasive metastasis detection provided by (18F-FDG PET/CT) is valuable as it allows for the modification of the initial staging, which in turn affects the treatment regimens for newly diagnosed breast cancer patients.

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Section: Resultsmentioning

confidence: 94%

Role of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in evaluation of newly diagnosed breast cancer patients

Esmail,

Abdulsalam,

Khatab

et al. 2023

Zagazig University Medical Journal

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“…18F-FDG PET-CT is currently regarded as an indispensable part of the evaluation of oncological patients due to its capacity to better characterise malignancy and added usefulness in correctly staging patients whose malignancy is later confirmed [ 1 ]. In oncology, tissue sampling is essential for making correct diagnostic and therapy decisions.…”

Section: Introductionmentioning

confidence: 99%

The Role of PET-CT-Guided Metabolic Biopsies in Improving Yield of Inconclusive Anatomical Biopsies: A Review of 5 Years in a Teaching Hospital

et al. 2023

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Tumour sampling is indispensable to diagnostic and therapeutic decision making. Thus, 18F-FDG PET/CT has the potential to accurately discriminate between viable and non-viable tissues due to its ability to characterise the metabolism of visible tissues. This study’s objective was to evaluate the incremental utility of 18F-FDG PET-CT-guided metabolic biopsy in individuals with suspected lesions and a previous negative anatomical biopsy. This study included a total of 190 consecutive patients with probable malignancy and who had experienced a previous unsuccessful anatomical biopsy who underwent PET-CT-guided metabolic biopsy. We retrospectively analysed the patients’ medical records and imaging investigations to assess demographics, complications, pathologies, and final clinical diagnoses. Using multivariate logistic regression, correlation between several confounding factors that lead to post-procedural problems was evaluated. Adequate material was obtained in all patients, and 162 (85%) were found to be positive for malignancy with a diagnostic yield of 96.9%. In 25 (13.1%) patients, post-procedural complications were reported, with pneumothorax being the most prevalent issue. In evaluating oncological patients, metabolic biopsy provides a safer alternative therapy with a high diagnostic yield and comparable complications. PET-CT, being an essential component of cancer staging, may serve as a one-stop shop for the management of these patients’ conditions.

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Accuracy of positron emission tomography-computed tomography in the assessment of metabolically negative axillary lymph nodes in breast cancer

Salama,

Swilem,

Zidan

et al. 2024

The Egyptian Journal of Surgery

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Background Breast cancer is a significant public health concern, and early detection of breast lesions is crucial for improved patient outcomes. Accurate assessment of axillary lymph node involvement in breast cancer is vital for staging and treatment decisions. The purpose of this study was to assess to what extent positron emission tomography (PET)-computed tomography (CT) can be used in the assessment of negative axillary lymph nodes in breast cancer and to determine if pathological variability can affect the result of the PET-CT. Patients and methods This prospective study was carried out on 50 female patients with locally advanced breast cancer and with negative PET-CT scans for active axillary lymph nodes. All studied cases underwent postoperative pathological examination to be compared with preoperative PET-CT results. Results Of the studied cases, 84% showed negative axillary lymph node involvement. PET/CT exhibited high sensitivity (95.24%) and specificity (87.5%) in predicting positive nodes, with an axillary maximum standardized uptake value cutoff value of 4.22 (area under the curve=0.923). Logistic regression revealed a significant association between higher T stage and positive lymph nodes (P<0.05). Conclusion PET/CT demonstrates strong predictive accuracy in detecting metabolically negative axillary lymph nodes in breast cancer patients.

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Role of 18F-FDG PET/CT in evaluation of recently diagnosed breast cancer patients

Cited by 3 publications

References 30 publications

Role of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in evaluation of newly diagnosed breast cancer patients

Role of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in evaluation of newly diagnosed breast cancer patients

The Role of PET-CT-Guided Metabolic Biopsies in Improving Yield of Inconclusive Anatomical Biopsies: A Review of 5 Years in a Teaching Hospital

Accuracy of positron emission tomography-computed tomography in the assessment of metabolically negative axillary lymph nodes in breast cancer

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