Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease

Rao, Swetha Pavani; Dobariya, Prakashkumar; Bellamkonda, Harshini; More, Swati S.

doi:10.3390/antiox12030603

Cited by 15 publications

(6 citation statements)

References 126 publications

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“…Our results showed that only 3MST expression was not boosted by taurine supplementation. Unlike other H 2 S-producing enzymes, 3MST is located in the mitochondria and catalyzes the production of H 2 S with 3-mercaptopyruvate as the donor of sulfur [31]. Further studies are required to investigate whether taurine differentially regulates H 2 S-producing enzyme expression for such reasons.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease

Tain,

Hou,

Chang-Chien

et al. 2023

Antioxidants

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Taurine is a natural antioxidant with antihypertensive properties. Maternal chronic kidney disease (CKD) has an impact on renal programming and increases the risk of offspring hypertension in later life. The underlying mechanisms cover oxidative stress, a dysregulated hydrogen sulfide (H2S) system, dysbiotic gut microbiota, and inappropriate activation of the renin–angiotensin–aldosterone system (RAAS). We investigated whether perinatal taurine administration enables us to prevent high blood pressure (BP) in offspring complicated by maternal CKD. Before mating, CKD was induced through feeding chow containing 0.5% adenine for 3 weeks. Taurine was administered (3% in drinking water) during gestation and lactation. Four groups of male offspring were used (n = 8/group): controls, CKD, taurine-treated control rats, and taurine-treated rats with CKD. Taurine treatment significantly reduced BP in male offspring born to mothers with CKD. The beneficial effects of perinatal taurine treatment were attributed to an augmented H2S pathway, rebalance of aberrant RAAS activation, and gut microbiota alterations. In summary, our results not only deepen our knowledge of the mechanisms underlying maternal CKD-induced offspring hypertension but also afford us the impetus to consider taurine-based intervention as a promising preventive approach for future clinical translation.

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Section: Discussionmentioning

confidence: 99%

Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease

Tain,

Hou,

Chang-Chien

et al. 2023

Antioxidants

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“…The human 3MST enzyme is encoded by the MPST gene on the long arm of chromosome 22 in the subtelomeric region q13.1 [ 125 ]. The MPST gene is 5.6 kbp in length with only two exon regions [ 126 ].…”

Section: H 2 S Enzymatic Machinerymentioning

confidence: 99%

Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review

Youness,

Habashy,

Khater

et al. 2024

ncRNA

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Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a “Maestro” role in orchestrating several oncological and non-oncological circuits and, thus, nominated them as possible therapeutic targets. Although a significant amount of work has been conducted on the role of nitric oxide (NO) and carbon monoxide (CO) and their inter-relationship in the field of oncology, research about hydrogen sulfide (H2S) remains in its infancy. Recently, non-coding RNAs (ncRNAs) have been reported to play a dominating role in the regulation of the endogenous machinery system of H2S in several pathological contexts. A growing list of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are leading the way as upstream regulators for H2S biosynthesis in different mammalian cells during the development and progression of human diseases; therefore, their targeting can be of great therapeutic benefit. In the current review, the authors shed the light onto the biosynthetic pathways of H2S and their regulation by miRNAs and lncRNAs in various oncological and non-oncological disorders.

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“…Mercaptopyruvatesulfurtransferase (3MST) belongs to the family of sulfurtransferases, which catalyze the transfer of a sulfur from a sulfur donor to a thiophilic acceptor by the formation of a protein cysteine persulfur intermediate [52]. The sulfur atom donor is 3-mercaptopyruvate, and the kinetically favored acceptor under physiological conditions is thioredoxin [53] (Figure 6).…”

Section: Figurementioning

confidence: 99%

Chemistry of Hydrogen Sulfide—Pathological and Physiological Functions in Mammalian Cells

Andrés,

Pérez de la Lastra,

Andrés Juan

et al. 2023

Cells

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Hydrogen sulfide (H2S) was recognized as a gaseous signaling molecule, similar to nitric oxide (-NO) and carbon monoxide (CO). The aim of this review is to provide an overview of the formation of hydrogen sulfide (H2S) in the human body. H2S is synthesized by enzymatic processes involving cysteine and several enzymes, including cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), cysteine aminotransferase (CAT), 3-mercaptopyruvate sulfurtransferase (3MST) and D-amino acid oxidase (DAO). The physiological and pathological effects of hydrogen sulfide (H2S) on various systems in the human body have led to extensive research efforts to develop appropriate methods to deliver H2S under conditions that mimic physiological settings and respond to various stimuli. These functions span a wide spectrum, ranging from effects on the endocrine system and cellular lifespan to protection of liver and kidney function. The exact physiological and hazardous thresholds of hydrogen sulfide (H2S) in the human body are currently not well understood and need to be researched in depth. This article provides an overview of the physiological significance of H2S in the human body. It highlights the various sources of H2S production in different situations and examines existing techniques for detecting this gas.

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Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease

Cited by 15 publications

References 126 publications

Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease

Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease

Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review

Chemistry of Hydrogen Sulfide—Pathological and Physiological Functions in Mammalian Cells

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